Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2017 Jun;33(3):359-360.
doi: 10.1007/s12264-017-0130-5. Epub 2017 Apr 7.

Homeostasis of Synapses: Expansion During Wakefulness, Contraction During Sleep

Affiliations
Comment

Homeostasis of Synapses: Expansion During Wakefulness, Contraction During Sleep

Chao He et al. Neurosci Bull. 2017 Jun.
No abstract available

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
During sleep, synaptic sizes shrink and glutamate receptor levels decrease. This is driven by the Homer1a-induced remodeling of the mGluR5 signaling complex. Dashed lines (right) indicate the profile of the synapse in the awake state.

Comment on

References

    1. Xie M, Li C, He C, Yang L, Tan G, Yan J, et al. Short-term sleep deprivation disrupts the molecular composition of ionotropic glutamate receptors in entorhinal cortex and impairs the rat spatial reference memory. Behav Brain Res. 2016;300:70–76. doi: 10.1016/j.bbr.2015.10.002. - DOI - PubMed
    1. Xie M, Yan J, He C, Yang L, Tan G, Li C, et al. Short-term sleep deprivation impairs spatial working memory and modulates expression levels of ionotropic glutamate receptor subunits in hippocampus. Behav Brain Res. 2015;286:64–70. doi: 10.1016/j.bbr.2015.02.040. - DOI - PubMed
    1. Tononi G, Cirelli C. Sleep and synaptic homeostasis: a hypothesis. Brain Res Bull. 2003;62:143–150. doi: 10.1016/j.brainresbull.2003.09.004. - DOI - PubMed
    1. Tononi G, Cirelli C. Sleep function and synaptic homeostasis. Sleep Med Rev. 2006;10:49–62. doi: 10.1016/j.smrv.2005.05.002. - DOI - PubMed
    1. Li Y, Chen F, Hu ZA. Weakening synapse to baseline during sleep. Prog Biochem Biophys. 2009;36:269–273. doi: 10.3724/SP.J.1206.2008.00443. - DOI

LinkOut - more resources