Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Sep;106(9):2204-2208.
doi: 10.1016/j.xphs.2017.03.036. Epub 2017 Apr 5.

Physiologically Based Pharmacokinetic Modeling of Drug Transporters to Facilitate Individualized Dose Prediction

Aleksandra Galetin  1 , Ping Zhao  2 , Shiew-Mei Huang  2
Affiliations
Review

Physiologically Based Pharmacokinetic Modeling of Drug Transporters to Facilitate Individualized Dose Prediction

Aleksandra Galetin et al. J Pharm Sci. 2017 Sep.

Abstract

Physiologically based pharmacokinetic modeling is a commonly used strategy in the drug development and regulatory submissions. This commentary provides a critical overview of the current status of physiologically based pharmacokinetic methodologies to predict transporter-mediated pharmacokinetics, in addition to the impact of disease and genetics with respect to local and systemic concentration.

Keywords: pharmacokinetic/pharmacodynamic models; transporters.

PubMed Disclaimer

Publication types

MeSH terms

Substances

LinkOut - more resources