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. 2017 Feb 1;19(2):162-174.
doi: 10.1093/neuonc/now241.

Diagnosis and treatment of brain metastases from solid tumors: guidelines from the European Association of Neuro-Oncology (EANO)

Riccardo Soffietti  1 , Ufuk Abacioglu  2 , Brigitta Baumert  3 , Stephanie E Combs  4 , Sara Kinhult  5 , Johan M Kros  6 , Christine Marosi  7 , Philippe Metellus  7   8 , Alexander Radbruch  9 , Salvador S Villa Freixa  10 , Michael Brada  11 , Carmine M Carapella  12 , Matthias Preusser  13 , Emilie Le Rhun  14 , Roberta Rudà  1 , Joerg C Tonn  15 , Damien C Weber  16 , Michael Weller  17
Affiliations

Diagnosis and treatment of brain metastases from solid tumors: guidelines from the European Association of Neuro-Oncology (EANO)

Riccardo Soffietti et al. Neuro Oncol. .

Abstract

The management of patients with brain metastases has become a major issue due to the increasing frequency and complexity of the diagnostic and therapeutic approaches. In 2014, the European Association of Neuro-Oncology (EANO) created a multidisciplinary Task Force to draw evidence-based guidelines for patients with brain metastases from solid tumors. Here, we present these guidelines, which provide a consensus review of evidence and recommendations for diagnosis by neuroimaging and neuropathology, staging, prognostic factors, and different treatment options. Specifically, we addressed options such as surgery, stereotactic radiosurgery/stereotactic fractionated radiotherapy, whole-brain radiotherapy, chemotherapy and targeted therapy (with particular attention to brain metastases from non-small cell lung cancer, melanoma and breast and renal cancer), and supportive care.

Keywords: brain metastases; chemotherapy; neuroimaging; neuropathology; stereotactic radiosurgery/stereotactic fractionated radiotherapy; supportive care; surgery; targeted therapy; whole-brain radiation therapy.

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