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Review
. 1987 Dec;1(4):349-55.
doi: 10.1016/0889-1591(87)90038-9.

Paraneoplastic limbic encephalopathy

E G Camara  1 , G J Chelune
Affiliations
Review

Paraneoplastic limbic encephalopathy

E G Camara et al. Brain Behav Immun. 1987 Dec.

Abstract

Paraneoplastic limbic encephalopathy (PLE) is a remote, nonmetastatic complication of carcinoma. Neuropsychiatric symptoms consists of cognitive, affective, and behavioral changes that can predate the diagnosis of carcinoma by as much as 6 years. The most striking feature is the development of an amnestic syndrome without generalized intellectual decline. We report a case of PLE, including neuropsychological test results, and review the features of similar cases in the literature. The postulated causes and clinical implications of PLE are discussed.

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