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Meta-Analysis
. 2017 Apr 10;11(4):e0005521.
doi: 10.1371/journal.pntd.0005521. eCollection 2017 Apr.

Seroprevalence of Q fever among human and animal in Iran; A systematic review and meta-analysis

Ashraf Mohabbati Mobarez  1 , Fahimeh Bagheri Amiri  2   3 , Saber Esmaeili  1   4
Affiliations
Meta-Analysis

Seroprevalence of Q fever among human and animal in Iran; A systematic review and meta-analysis

Ashraf Mohabbati Mobarez et al. PLoS Negl Trop Dis. .

Abstract

Background: Q fever is a main zoonotic disease around the world. The aim of this meta-analysis was to estimate the overall seroprevalence of Coxiella burnetii among human and animal population in Iran.

Methods: Major national and international databases were searched from 2005 up to August 2016. We extracted the prevalence of Q fever antibodies (IgG) as the main primary outcome. We reported the prevalence of the seropositivity as point and 95% confidence intervals.

Results: The overall seroprevalence of IgG phase I and II antibodies of Q fever in human was 19.80% (95% CI: 16.35-23.25%) and 32.86% (95% CI: 23.80-41.92%), respectively. The herd and individual prevalence of C. burnetii antibody in goat were 93.42% (95% CI: 80.23-100.00) and 31.97% (95% CI: 20.96-42.98%), respectively. The herd and individual prevalence of Q fever antibody in sheep's were 96.07% (95% CI: 89.11-100.00%) and 24.66% (95% CI: 19.81-29.51%), respectively. The herd and individual prevalence of C. burnetii antibody in cattle were 41.37% (95% CI: 17.88-64.86%) and 13.30% (95% CI: 2.98-23.62%), respectively. Individual seropositivity of Q fever in camel and dog were 28.26% (95% CI: 21.47-35.05) and 0.55% (0.03-2.68), respectively.

Conclusion: Seroprevalence of Q fever among human and domestic animals is considerable. Preventative planning and control of C. burnetii infections in Iran is necessary. Active surveillance and further research studies are recommended, to more clearly define the epidemiology and importance of C. burnetii infections in animals and people in Iran.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Flow diagram of included and excluded records
Fig 2
Fig 2
Geographical distribution of anti- C. burnetii IgG Phase I (A) and IgG Phase II (B) among Iranian people.
Fig 3
Fig 3
Geographical distribution of Q fever seropositivity among goats in individual (A) and herd (B) levels in the Iran.
Fig 4
Fig 4
Geographical distribution of C. burnetii seroprevalence among sheep’s in individual (A) and herd (B) levels in Iran.
Fig 5
Fig 5
Geographical distribution of Q fever seropositivity among cattle’s in individual (A) and herd (B) levels in Iran.
See this image and copyright information in PMC

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