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. 2017 Jun;69(6):1036-1044.
doi: 10.1161/HYPERTENSIONAHA.116.08998. Epub 2017 Apr 10.

Asymptomatic Hyperuricemia Without Comorbidities Predicts Cardiometabolic Diseases: Five-Year Japanese Cohort Study

Masanari Kuwabara  1 , Koichiro Niwa  2 , Ichiro Hisatome  2 , Takahiko Nakagawa  2 , Carlos A Roncal-Jimenez  2 , Ana Andres-Hernando  2 , Petter Bjornstad  2 , Thomas Jensen  2 , Yuka Sato  2 , Tamara Milagres  2 , Gabriela Garcia  2 , Minoru Ohno  2 , Miguel A Lanaspa  2 , Richard J Johnson  2
Affiliations

Asymptomatic Hyperuricemia Without Comorbidities Predicts Cardiometabolic Diseases: Five-Year Japanese Cohort Study

Masanari Kuwabara et al. Hypertension. 2017 Jun.

Abstract

Whether asymptomatic hyperuricemia in the absence of comorbidities increases the risk for cardiometabolic disorders and chronic kidney disease remains controversial. This study was conducted to clarify the association between asymptomatic hyperuricemia and cardiometabolic conditions. Subjects consisting of Japanese adults between 30 and 85 years of age were enrolled in the study at Center for Preventive Medicine, St Luke's International Hospital, Tokyo, and were available at enrollment (2004) and at 5-year follow-up (2009). Subjects were excluded if they were overweight or obese, hypertensive, diabetic, and dyslipidemic, had a history of gout or hyperuricemia on medications, or had chronic kidney disease as estimated glomerular filtration rate <60 mL/min per 1.73 m2 Linear and logistic regression analyses were used to examine the relationship between hyperuricemia and development of hypertension, diabetes mellitus, dyslipidemia, chronic kidney disease, and overweight/obesity (unadjusted and adjusted for age, sex, smoking, drinking habits, baseline estimated glomerular filtration rate, and body mass index). Five thousand eight hundred and ninety-nine subjects without comorbidities (mean age of 47±10 years, 1864 men) were followed for 5 years. Hyperuricemia (defined as >7 mg/dL in men and ≥6 mg/dL in women) was associated with increased cumulative incidence of hypertension (14.9% versus 6.1%; P<0.001), dyslipidemia (23.1% versus 15.5%; P<0.001), chronic kidney disease (19.0% versus 10.7%; P<0.001), and overweight/obesity (8.9% versus 3.0%; P<0.001), while diabetes mellitus (1.7% versus 0.9%; P=0.087) showed a trend but did not reach statistical significance. In conclusion, asymptomatic hyperuricemia carries a significant risk for developing cardiometabolic conditions in Japanese individual without comorbidities.

Keywords: asymptomatic hyperuricemia; cardiovascular disease risk factors; epidemiology; hypertension; uric acid.

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Conflict of interest statement

Conflict of interest: Dr. Kuwabara reports the grant for studying abroad from Federation of National Public Service Personnel Mutual Aid Association in Japan; Dr. Sato reports the grant for studying abroad from Japan Society Promotion Science; Dr. Bjornstad is funded by a NIH training grant (T32 DK063687); Dr. Johnson reports other from XORT Therapeutics, during the conduct of the study; personal fees from Amway, other from Colorado Research Partners; In addition, Dr. Johnson has a patent US Patent No 7,799,794 licensed to XORT therapeutics, a patent US Patent No. 8,557,831 licensed to XORT Therapeutics, and a patent Serial No. 13/364,313 licensed to XORT Therapeutics.

Figures

Figure 1
Figure 1. Flow diagram of study enrollment. Study subjects whose eGFR ≥60 ml/min/1.73m2
N: number of subjects, BMI: body mass index
Figure 2
Figure 2. The cumulative incidence rates of hypertension, diabetes mellitus, dyslipidemia, chronic kidney disease, and overweight/obesity over 5 years between hyperuricemia and normouricemia. Study subjects whose eGFR ≥60 ml/min/1.73m2
Significant differences of cumulative incidence rates between normouricemia and hyperuricemia showed as *p<0.05, **p<0.01, ***p<0.001 by χ2 analyses.
Figure 3
Figure 3. The cumulative incidence rates of hypertension, diabetes mellitus, dyslipidemia, chronic kidney disease and overweight/obesity over 5 years in each serum uric acid level. Study subjects whose eGFR ≥60 ml/min/1.73m2
The number of subjects was 10, 93, 283, 661, 657, 230, 55 in men and 276, 1,363, 1,735, 552, 101, 14, 0 in women in each serum uric acid level: ≤3.0, 3.1-4.0, 4.1-5.0, 5.1-6.0, 6.1-7.0, 7.1-8.0, 8.1 mg/dL ≤, respectively.
See this image and copyright information in PMC

Comment in

References

    1. Johnson RJ, Kang DH, Feig D, Kivlighn S, Kanellis J, Watanabe S, Tuttle KR, Rodriguez-Iturbe B, Herrera-Acosta J, Mazzali M. Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? Hypertension. 2003;41:1183–1190. - PubMed
    1. Mazzali M, Hughes J, Kim YG, Jefferson JA, Kang DH, Gordon KL, Lan HY, Kivlighn S, Johnson RJ. Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism. Hypertension. 2001;38:1101–1106. - PubMed
    1. Kang DH, Nakagawa T, Feng L, Watanabe S, Han L, Mazzali M, Truong L, Harris R, Johnson RJ. A role for uric acid in the progression of renal disease. J Am Soc Nephrol. 2002;13:2888–2897. - PubMed
    1. Nakagawa T, Hu H, Zharikov S, Tuttle KR, Short RA, Glushakova O, Ouyang X, Feig DI, Block ER, Herrera-Acosta J, Patel JM, Johnson RJ. A causal role for uric acid in fructose-induced metabolic syndrome. Am J Physiol Renal Physiol. 2006;290:F625–631. - PubMed
    1. Grayson PC, Kim SY, LaValley M, Choi HK. Hyperuricemia and incident hypertension: A systematic review and meta-analysis. Arthritis Care Res (Hoboken) 2011;63:102–110. - PMC - PubMed

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