Healthy children without fear: Reproductive options for patients or couples carrying inherited diseases
- PMID: 28396574
- PMCID: PMC5412770
- DOI: 10.15252/embr.201744253
Healthy children without fear: Reproductive options for patients or couples carrying inherited diseases
Abstract
Prenatal diagnostics and preimplantation genetic screening are safe and efficient methods to help parents with inherited mutations for severe diseases to have healthy children. Its expansion into adult‐onset diseases and cancer raises challenges for regulation of assisted reproductive technologies and coverage by healthcare systems.
References
-
- Scott RT Jr, Upham KM, Forman EJ, Zhao T, Treff NR (2013) Cleavage‐stage biopsy significantly impairs human embryonic implantation potential while blastocyst biopsy does not: a randomized and paired clinical trial. Fertil Steril 100: 624–630 - PubMed
-
- Calle A, Fernandez‐Gonzalez R, Ramos‐Ibeas P, Laguna‐Barraza R, Perez‐Cerezales S, Bermejo‐Alvarez P, Ramirez MA, Gutierrez‐Adan A (2012) Long‐term and transgenerational effects of in vitro culture on mouse embryos. Theriogenology 77: 785–793 - PubMed
-
- Handyside AH, Harton GL, Mariani B, Thornhill AR, Affara N, Shaw MA, Griffin DK (2010) Karyomapping: a universal method for genome wide analysis of genetic disease based on mapping crossovers between parental haplotypes. J Med Genet 47: 651–658 - PubMed
-
- Lo YM, Corbetta N, Chamberlain PF, Rai V, Sargent IL, Redman CW, Wainscoat JS (1997) Presence of fetal DNA in maternal plasma and serum. Lancet 350: 485–487 - PubMed
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