Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Aug;42(8):2344-2353.
doi: 10.1007/s11064-017-2252-6. Epub 2017 Apr 10.

Taurine Promotes the Cartilaginous Differentiation of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Vitro

Xiuhua Yao  1 , Huiling Huang  2 , Zhou Li  3 , Xiaohua Liu  4 , Weijia Fan  1 , Xinping Wang  5 , Xuelian Sun  4 , Jianmin Zhu  4 , Hongrui Zhou  3 , Huaying Wei  4
Affiliations

Taurine Promotes the Cartilaginous Differentiation of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Vitro

Xiuhua Yao et al. Neurochem Res. 2017 Aug.

Abstract

Taurine has been reported to influence osteogenic differentiation, but the role of taurine on cartilaginous differentiation using human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) remains unclear. In this study, we investigated the effect of taurine (0, 1, 5 and 10 mM) on the proliferation and chondrogenesis of hUC-MSCs by analyzing cell proliferation, accumulation of glycosaminoglycans and expression of cartilage specific mRNA. The results show though taurine did not affected the proliferation of hUC-MSCs, 5 mM of taurine is sufficient to enhanced the accumulation of glycosaminoglycans and up-regulate cartilage specific mRNA expression, namely collagen type II, aggrecan and SOX9. Taurine also inhibits chondrocyte dedifferentiation by reducing expression of collagen type I mRNA. Taken together, our study reveals that taurine promotes and maintains the chondrogenesis of hUC-MSCs.

Keywords: Chondrogenesis; Human mesenchymal stem cells; Taurine; Umbilical cord.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. J Bone Joint Surg Br. 2004 Mar;86(2):286-95 - PubMed
    1. Clin Calcium. 2011 Jun;21(6):845-51 - PubMed
    1. J Bone Joint Surg Am. 1998 Dec;80(12):1745-57 - PubMed
    1. J Biomech Eng. 1995 May;117(2):179-92 - PubMed
    1. Stem Cells. 2008 Mar;26(3):591-9 - PubMed

MeSH terms

LinkOut - more resources