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Meta-Analysis
. 2017 Apr 20;130(8):979-985.
doi: 10.4103/0366-6999.204102.

Glutathione S-transferase P1 Ile105Val Polymorphism and Male Infertility Risk: An Updated Meta-analysis

Xue-Kun Huang  1 , Yong-Han Huang  1 , Juan-Hua Huang  1 , Jing-Yao Liang  2
Affiliations
Meta-Analysis

Glutathione S-transferase P1 Ile105Val Polymorphism and Male Infertility Risk: An Updated Meta-analysis

Xue-Kun Huang et al. Chin Med J (Engl). .

Abstract

Background: Several studies concerning the association between glutathione S-transferase P1 (GSTP1) Ile105Val polymorphism and male infertility risk have reported controversial findings. The present study was aimed to explore this association using a meta-analysis.

Methods: The PubMed, EMBASE, China National Knowledge Infrastructure (CNKI), and Wanfang databases were searched. Odds ratios (OR s) with 95% confidence intervals (CI s) were calculated to estimate the strength of the association.

Results: A total of 3282 cases and 3268 controls in nine case-control studies were included. There was no significant association between GSTP1 Ile105Val polymorphism and male infertility in the overall population, but significant associations were found under the dominant (OR = 1.23, 95% CI = 1.04-1.46, I2 = 32.2%) and heterozygote (OR = 1.29, 95% CI = 1.08-1.53, I2 = 26.8%) models after excluding studies for which the data did not satisfy Hardy-Weinberg equilibrium (HWE). Similarly, subgroup analyses revealed no significant association in Asians or Chinese population although a significant association was apparent among Chinese population in studies with HWE under the heterozygote model (OR = 1.25, 95% CI = 1.03-1.52, I2 = 44.1%). Significant heterogeneity could be observed in some genetic models, but this heterogeneity was not significant when stratified by HWE. No evidence for publication bias was found.

Conclusions: The GSTP1 Ile105Val polymorphism might not be associated with male infertility risk, and thus additional well-designed studies with larger sample size are warranted.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Flow chart of the study selection process.
Figure 2
Figure 2
Forest plot of the glutathione S-transferase P1 Ile105Val polymorphism associated with male infertility susceptibility in (a) the overall population and (b) the overall population in studies with Hardy-Weinberg equilibrium under dominant model (Val/Val + Ile/Val vs. Ile/Ile), and (c) the overall population and (d) the overall population in studies with Hardy-Weinberg equilibrium under heterozygote model (Ile/Val vs. Ile/Ile). OR: Odds ratio; CI: Confidence interval.
Figure 3
Figure 3
Analysis of funnel plot asymmetry and publication bias for the associations between glutathione S-transferase P1 Ile105Val polymorphism and male infertility in the overall population under (a) dominant (Val/Val + Ile/Val vs. Ile/Ile; P = 0.399) and (b) heterozygote (Ile/Val vs. Ile/Ile; P = 0.367) models.
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