Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Apr 8;9(4):132.
doi: 10.3390/toxins9040132.

Helicobacter pylori Strains and Gastric MALT Lymphoma

Pauline Floch  1 , Francis Mégraud  2 , Philippe Lehours  3
Affiliations
Review

Helicobacter pylori Strains and Gastric MALT Lymphoma

Pauline Floch et al. Toxins (Basel). .

Abstract

This article summarizes the main findings concerning Helicobacter pylori associated with gastric MALT lymphoma (GML). Considered together, GML strains based on their virulence factor profile appear to be less virulent than those associated with peptic ulcers or gastric adenocarcinoma. A particular Lewis antigen profile has been identified in GML strains and could represent an alternative adaptive mechanism to escape the host immune response thereby allowing continuous antigenic stimulation of infiltrating lymphocytes.

Keywords: Helicobacter pylori; MALT lymphoma; cag pathogenicity island; pathogenesis; virulence marker.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Pereira M.-I., Medeiros J.A. Role of Helicobacter pylori in gastric mucosa-associated lymphoid tissue lymphomas. World J. Gastroenterol. 2014;20:684–698. doi: 10.3748/wjg.v20.i3.684. - DOI - PMC - PubMed
    1. Zucca E., Copie-Bergman C., Ricardi U., Thieblemont C., Raderer M., Ladetto M. Gastric marginal zone lymphoma of MALT type: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann. Oncol. 2013;24:vi144–vi148. doi: 10.1093/annonc/mdt343. - DOI - PubMed
    1. Malfertheiner P., Megraud F., O’Morain C.A., Atherton J., Axon A.T., Bazzoli F., Gensini G.F., Gisbert J.P., Graham D.Y., Rokkas T., et al. Management of Helicobacter pylori infection—The Maastricht IV/ Florence Consensus Report. Gut. 2012;61:646–664. doi: 10.1136/gutjnl-2012-302084. - DOI - PubMed
    1. Wotherspoon A.C., Doglioni C., Diss T.C., Pan L., Moschini A., de Boni M., Isaacson P.G. Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori. Lancet. 1993;342:575–577. doi: 10.1016/0140-6736(93)91409-F. - DOI - PubMed
    1. Weber D.M., Dimopoulos M.A., Anandu D.P., Pugh W.C., Steinbach G. Regression of gastric lymphoma of mucosa-associated lymphoid tissue with antibiotic therapy for Helicobacter pylori. Gastroenterology. 1994;107:1835–1838. doi: 10.1016/0016-5085(94)90828-1. - DOI - PubMed

MeSH terms

LinkOut - more resources