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Comment
. 2017 Sep;27(9):1077-1078.
doi: 10.1038/cr.2017.53. Epub 2017 Apr 11.

An mRNA-based vaccine strategy against Zika

Gary Wong  1   2 , George F Gao  1   2
Affiliations
Comment

An mRNA-based vaccine strategy against Zika

Gary Wong et al. Cell Res. 2017 Sep.

Abstract

Infections with Zika virus are strongly associated with complications such as congenital microcephaly and can trigger Guillain-Barré syndrome in humans, highlighting the urgent need for a safe, efficacious vaccine as a preventative countermeasure. In a recent paper published in Cell, Richner et al. generated a lipid nanoparticle encapsulated modified mRNA vaccine encoding the prM and E genes from Zika virus, which showed protection and sterilizing immunity in immunocompetent mice.

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Comment on

  • Modified mRNA Vaccines Protect against Zika Virus Infection.
    Richner JM, Himansu S, Dowd KA, Butler SL, Salazar V, Fox JM, Julander JG, Tang WW, Shresta S, Pierson TC, Ciaramella G, Diamond MS. Richner JM, et al. Cell. 2017 Mar 9;168(6):1114-1125.e10. doi: 10.1016/j.cell.2017.02.017. Epub 2017 Feb 17. Cell. 2017. PMID: 28222903 Free PMC article.

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