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Comment
. 2017 Apr 10;41(1):7-9.
doi: 10.1016/j.devcel.2017.03.020.

Hematopoiesis Lineage Tree Uprooted: Every Cell Is a Rainbow

Karen K Hirschi  1 , Stefania Nicoli  2 , Kenneth Walsh  3
Affiliations
Comment

Hematopoiesis Lineage Tree Uprooted: Every Cell Is a Rainbow

Karen K Hirschi et al. Dev Cell. .

Abstract

Differentiation of hematopoietic stem cells into distinct cell types was thought to occur through a series of discrete, stable progenitor states. Work from Velten et al. (2017) now shows that hematopoietic cells differentiate via a mechanism of continuous lineage priming and thus represent a CLOUD-HSPC.

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Figures

Figure 1.
Figure 1.. Generic Models of Lineage Commitment
(A) Lineage tree model: The most oligo-potent cell is depicted in white, and transitions via binary fate decisions to ultimately generate distinct cell lineages are depicted in vibrant, distinct colors. (B) Lineage continuum model: All oligo-potent cells are highly transcriptionally diverse and undergo direct lineage commitment to generate distinct cell types, as opposed to transitioning through a series of discrete and stable progenitors.
See this image and copyright information in PMC

Comment on

  • Human haematopoietic stem cell lineage commitment is a continuous process.
    Velten L, Haas SF, Raffel S, Blaszkiewicz S, Islam S, Hennig BP, Hirche C, Lutz C, Buss EC, Nowak D, Boch T, Hofmann WK, Ho AD, Huber W, Trumpp A, Essers MA, Steinmetz LM. Velten L, et al. Nat Cell Biol. 2017 Apr;19(4):271-281. doi: 10.1038/ncb3493. Epub 2017 Mar 20. Nat Cell Biol. 2017. PMID: 28319093 Free PMC article.

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