Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2017 Apr 10;31(4):467-469.
doi: 10.1016/j.ccell.2017.03.008.

Data Triumph at C

Mark Levine  1 , Pierre-Christian Violet  2
Affiliations
Comment

Data Triumph at C

Mark Levine et al. Cancer Cell. .

Abstract

Despite historical controversy, pharmacologic ascorbate is emerging as promising cancer therapy via pro-oxidant chemistry. In this issue of Cancer Cell, Schoenfeld et al. describe how intracellular iron pools and reactive oxygen species drive pharmacologic ascorbate's selective toxicity to cancer cells in vitro, in mice, and in humans.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.. Pharmacologic Ascorbate Mediation of Cancer Cell Death
Pharmacologic ascorbate is a pro-drug for formation of extracellular H2O2. H2O2 diffuses intracellularly and interacts with iron or other metal centers to form reactive oxygen species (ROS). ROS modulate multiple downstream pathways and targets that induce cancer cell death.
See this image and copyright information in PMC

Comment on

References

    1. Chen Q, Espey MG, Krishna MC, Mitchell JB, Corpe CP, Buettner GR, Shacter E, and Levine M (2005). Proc. Natl. Acad. Sci. USA 102, 13604–13609. - PMC - PubMed
    1. Chen Q, Espey MG, Sun AY, Lee JH, Krishna MC, Shacter E, Choyke PL, Pooput C, Kirk KL, Buettner GR, and Levine M (2007). Proc. Natl. Acad. Sci. USA 104, 8749–8754. - PMC - PubMed
    1. Chen Q, Espey MG, Sun AY, Pooput C, Kirk KL, Krishna MC, Khosh DB, Drisko J, and Levine M (2008). Proc. Natl. Acad. Sci. USA 105, 11105–11109. - PMC - PubMed
    1. Levine M, Padayatty SJ, and Espey MG (2011). Adv. Nutr. 2, 78–88. - PMC - PubMed
    1. Ma Y, Chapman J, Levine M, Polireddy K, Drisko J, and Chen Q (2014). Sci. Transl. Med. 6, 222ra18. - PubMed