Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Feb;12(2):214-215.
doi: 10.4103/1673-5374.200802.

Mitochondria in the context of Parkinson's disease

Patricia Villacé  1 , Rosa M Mella  1 , Danel Kortazar  1
Affiliations

Mitochondria in the context of Parkinson's disease

Patricia Villacé et al. Neural Regen Res. 2017 Feb.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Fluorescent Parkin-based preclinical model. After the addition of the mitochondrial membrane uncoupler carbonyl cyanide m-chlorophenyl hydrazone (CCCP) to the culture, the fluorescently tagged and stably expressed Parkin is recruited to the damaged mitochondria. The difference in the cellular fluorescence redistribution is highly appreciable; from a cytoplasmic distribution in the negative control, it turns into a vesicular pattern after CCCP treatment, corresponding to mitochondrial distribution.
See this image and copyright information in PMC

References

    1. Chen L, Xie Z, Turkson S, Zhuang X. A53T human alpha-synuclein overexpression in transgenic mice induces pervasive mitochondria macroautophagy defects preceding dopamine neuron degeneration. J Neurosci. 2015;35:890–905. - PMC - PubMed
    1. Hertz NT, Berthet A, Sos ML, Thorn KS, Burlingame AL, Nakamura K, Shokat KM. A neo-substrate that amplifies catalytic activity of parkinson's-disease-related kinase PINK1. Cell. 2013;154:737–747. - PMC - PubMed
    1. Lang AE, Lozano AM. Parkinson's disease. First of two parts. N Engl J Med. 1998;339:1044–1053. - PubMed
    1. Langston JW, Ballard P, tetrud JW, Irwin I. Chronick Parkinsonism in humans due to a product of meperidine-analog synthesis. Science. 1983;219:979–980. - PubMed
    1. Liang CL, Wang TT, Luby-Phelps K, german DC. Mitochondria mass is low in mouse substantia nigra dopamine neurons: Implications for Parkinson's disease. Exp Neurol. 2007;203:370–380. - PubMed

LinkOut - more resources