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. 2017 Jun;264(6):1290-1291.
doi: 10.1007/s00415-017-8486-z. Epub 2017 Apr 11.

Familial dysautonomia: a disease with hidden tears

Carlos E Mendoza-Santiesteban  1 , Jose-Alberto Palma  2 , Lucy Norcliffe-Kaufmann  2 , Horacio Kaufmann  3
Affiliations

Familial dysautonomia: a disease with hidden tears

Carlos E Mendoza-Santiesteban et al. J Neurol. 2017 Jun.
No abstract available

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Conflict of interest statement

Conflict of interest: All authors declare no conflict of interests.

Figures

Figure
Figure
A. Linear regression showing increasing baseline tear secretion with more preserved corneal sensitivity (R2=0.75; p<0.0001) suggesting that the lack of basal lacrimation in familial dysautonomia is related to the degree of impairment of sensory (afferent) corneal inputs. B. Tear secretion before and after topical eye administration of pilocarpine in familial dysautonomia. Lacrimation was measured with the Schirmer test on four occasions: (1) at baseline, (2) 30-minutes after instillation of placebo, (3) 30-minutes, and (4) 3-hours after pilocarpine instillation. Tear secretion more than tripled after 30-minutes after instillation of piloparpine 4% to the eye (ANOVA with Tukey post-hoc comparisons p<0.0001 versus baseline lacrimation), which persisted after 3 hours (ANOVA with Tukey post-hoc comparisons p<0.0001 vs. baseline lacrimation). Square points represent the average of the 32 eyes at each measurement.
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References

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