Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Jun;72(2):192-197.
doi: 10.1007/s11130-017-0609-2.

Protective Effect of Juglans regia L. Walnut Extract Against Oxidative DNA Damage

Cinzia Calcabrini  1   2 , Roberta De Bellis  1 , Umberto Mancini  1 , Luigi Cucchiarini  1 , Vilberto Stocchi  1 , Lucia Potenza  3
Affiliations

Protective Effect of Juglans regia L. Walnut Extract Against Oxidative DNA Damage

Cinzia Calcabrini et al. Plant Foods Hum Nutr. 2017 Jun.

Abstract

Walnuts (Juglans regia L.) are relevant components of the Mediterranean diet providing important macronutrients, micronutrients and other bioactive constituents including unsaturated fatty acids, proteins, fiber, vitamins, minerals, phytosterols and polyphenols. Although the walnut beneficial effects in human health are widely recognized by a lot of epidemiologic studies very little is known regarding its effect on damaged DNA. The aim of the present study was to investigate the effect of Juglans regia L. ethanolic extract from kernel on the induction of DNA strand breaks by thiol/Fe3+/O2 mixed function oxidase, tert-butyl hydroperoxide or UVC radiations in acellular and cellular models. Plasmid DNA cleavage and fast Halo assay were used to monitor oxidative damage to DNA. Both approaches showed protection of oxidatively injured DNA. These results agree with a lot of scientific proofs which recommend walnut as dietary adjunct in health promotion and prevention as well as in treatment of lifestyle-related oxidative diseases.

Keywords: DNA damage; Juglans regia L.; Keratinocytes; Oxidative stress.

PubMed Disclaimer

References

    1. J Nutr Biochem. 2015 Jul;26(7):776-83 - PubMed
    1. J Nutr. 2008 Sep;138(9):1746S-1751S - PubMed
    1. Plant Foods Hum Nutr. 2011 Nov;66(4):335-40 - PubMed
    1. Cancer Epidemiol Biomarkers Prev. 2004 Oct;13(10):1595-603 - PubMed
    1. J Sci Food Agric. 2010 Sep;90(12):1959-67 - PubMed

LinkOut - more resources