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. 2017 May 30;8(22):36545-36552.
doi: 10.18632/oncotarget.16614.

Association of CKIP-1 P21A polymorphism with risk of chronic heart failure in a Chinese population

Mu-Peng Li  1   2 , Yan-Jiao Zhang  1   2 , Xiao-Lei Hu  1   2 , Ji-Peng Zhou  1   2 , Yong-Long Yang  3 , Li-Ming Peng  4 , Hong Qi  4 , Tian-Lun Yang  4 , Xiao-Ping Chen  1   2
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Association of CKIP-1 P21A polymorphism with risk of chronic heart failure in a Chinese population

Mu-Peng Li et al. Oncotarget. .

Abstract

Pathological cardiac hypertrophy is an independent risk factor for chronic heart failure. Casein kinase-2 interacting protein-1 (CKIP-1) can inhibit pathological cardiac hypertrophy. Therefore, we investigated whether CKIP-1 nonsynonymous polymorphism rs2306235 (Pro21Ala) contributes to risk and prognosis of chronic heart failure in a Chinese population.A total of 923 adult patients with chronic heart failure and 1020 age- and gender-matched healthy controls were recruited. CKIP-1 rs2306235 polymorphism was genotyped using PCR-restriction fragment length polymorphism. Additional follow-up data for 140 chronic heart failure patients was evaluated. The rs2306235 G allele was associated with an increased risk of chronic heart failure (OR = 1.38, 95% CI = 1.09-1.75, p = 0.007), especially in patients with hypertension (OR = 1.45, 95% CI = 1.09-1.75, p = 0.006) and coronary heart disease (OR = 1.41, 95% CI = 1.09-1.83, p = 0.010) after adjustment for multiple cardiovascular risk factors. However, rs2306235 polymorphism was not associated with cardiovascular mortality in chronic heart failure (p = 0.875). CKIP-1 rs2306235 polymorphism may be a risk factor for chronic heart failure in a Chinese Han population.

Keywords: CKIP-1; cardiac hypertrophy; chronic heart failure; polymorphism; prognosis.

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Conflict of interest statement

CONFLICTS OF INTEREST

The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1. Association of CKIP-1 rs2306235 polymorphism with cardiovascular mortality in chronic heart failure patients
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