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Review
. 2017 Feb/Mar;25(1):13-16.

Kidney Disease and HIV Infection

Christina M Wyatt  1
Affiliations
Review

Kidney Disease and HIV Infection

Christina M Wyatt. Top Antivir Med. 2017 Feb/Mar.

Abstract

The risk of acute and chronic kidney disease remains higher in HIV-infected persons than in the general population, and kidney disease in HIV-infected persons is associated with poor outcomes, including increased mortality. HIV-associated nephropathy occurs less frequently in the era of antiretroviral therapy. HIV immune complex kidney disease is being diagnosed more frequently, but the term is currently used to refer to a heterogeneous group of kidney diseases. Comorbid chronic kidney disease poses a growing burden in HIV-infected persons due to an overrepresentation of risk factors such as black race, diabetes, hypertension, and coinfection with hepatitis C virus. Drug-induced kidney toxicity also remains a concern. This article summarizes a presentation by Christina M. Wyatt, MD, at the Ryan White HIV/AIDS Program Clinical Care Conference held in New Orleans, Louisiana, in December 2015.

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Figures

Figure 1.
Figure 1.
Proportion of hospitalizations among HIV-infected persons complicated by dialysis-dependent acute kidney injury (top), and adjusted odds ratio of in-hospital mortality associated with dialysis-dependent acute kidney injury (bottom). Adapted from Nadkarni et al.
Figure 2.
Figure 2.
Additive effect of HIV infection and diabetes on progression of chronic kidney disease. Adapted from Medapalli et al.
See this image and copyright information in PMC

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