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Review
. 2017 Nov;22(6):529-537.
doi: 10.1177/1074248417702976. Epub 2017 Apr 12.

Parathyroid Hormone-Related Peptide: A Novel Endocrine Cardioprotective "Conditioning Mimetic"

Tanuka Datta  1 , Karin Przyklenk  2   3   4 , Nabanita S Datta  2   5
Affiliations
Review

Parathyroid Hormone-Related Peptide: A Novel Endocrine Cardioprotective "Conditioning Mimetic"

Tanuka Datta et al. J Cardiovasc Pharmacol Ther. 2017 Nov.

Abstract

An as-yet limited body of evidence suggests that calcium-regulating endocrine hormones-in particular, parathyroid hormone-related peptide (PTHrP)-may have unappreciated cardioprotective effects. The current review focuses on the concept that PTHrP may, via modulation of classic cardioprotective signaling pathways, provide a novel strategy to attenuate myocardial ischemia-reperfusion injury.

Keywords: heart; ischemia; mitogen-activated protein kinase phosphatase 1; parathyroid hormone–related peptide; reperfusion.

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