Vitamin C puts the pedal to the metal

Affiliations

Comment

Monica Venere. Sci Transl Med. 2017.

. 2017 Apr 12;9(385):eaan2778.

doi: 10.1126/scitranslmed.aan2778.

¹ Department of Radiation Oncology and the Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43017, USA. Email: monica.venere@osumc.edu.

Abstract

Increased iron in cancer cells drives selective sensitization of tumors to ascorbate treatment to prolong survival.

O₂^⋅- and H₂O₂-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate.
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