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Case Reports
. 2017 Apr;30(2):186-189.
doi: 10.1080/08998280.2017.11929579.

Asian-variant intravascular large B-cell lymphoma

Derrick W Su  1 , Whitney Pasch  1 , Cristina Costales  1 , Imran Siddiqi  1 , Ann Mohrbacher  1
Affiliations
Case Reports

Asian-variant intravascular large B-cell lymphoma

Derrick W Su et al. Proc (Bayl Univ Med Cent). 2017 Apr.

Abstract

Intravascular large B-cell lymphoma (IVLBCL) is a rare and deadly malignancy involving the growth of lymphoma cells within vessel lumina of all organ types. IVLBCL is further divided into the hemophagocytic Asian variant and a classical Western variant. Both variants are difficult to diagnose by imaging, and although diagnostic criteria have been developed to guide workup, histopathological examination remains imperative. Treatment of IVLBCL remains difficult given the high mortality of the disease, but rituximab has emerged as a promising therapeutic option when combined with various cytotoxic regimens. The two main variants of IVLBCL generally manifest in their respective Asian or Western populations, and crossover between ethnicities is rare. We present the second described case of Asian-variant IVLBCL in an African American individual.

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Figures

Figure 1.
Figure 1.
Representative hematoxylin and eosin sections of atypical intravascular lymphocytes infiltrating capillaries of (a) lung, (b) thalamus, (c) esophagus, (d) bladder, (e) pancreas, and (f) psoas muscle. CD20 stain of (g) spleen and (h) bladder.
Figure 2.
Figure 2.
(a) Bone marrow, hematoxylin and eosin stain, and (b) CD68 immunohistochemical stain highlighting numerous hemophagocytic histiocytes.
See this image and copyright information in PMC

References

    1. Domizio P, Hall PA, Cotter F, Amiel S, Tucker J, Besser GM, Levison DA. Angiotropic large cell lymphoma (ALCL): morphological immunohistochemical and genotypic studies with analysis of previous reports. Hematol Oncol. 1989;7(3):195–206. - PubMed
    1. Ferreri AJ, Campo E, Seymour JF, Willemze R, Ilariucci F, Ambrosetti A, Zucca E, Rossi G, Lopez-Guillermo A, Pavlovsky MA, Geerts ML, Candoni A, Lestani M, Asioli S, Milani M, Piris MA, Pileri S, Facchetti F, Cavalli F, Ponzoni M. International Extranodal Lymphoma Study Group. Intravascular lymphoma: clinical presentation natural history management and prognostic factors in a series of 38 cases with special emphasis on the ‘cutaneous variant.’. Br J Haematol. 2004;127(2):173–183. - PubMed
    1. Shimada K, Kinoshita T, Naoe T, Nakamura S. Presentation and management of intravascular large B-cell lymphoma. Lancet Oncol. 2009;10(9):895–902. - PubMed
    1. Murase T, Nakamura S, Kawauchi K, Matsuzaki H, Sakai C, Inaba T, Nasu K, Tashiro K, Suchi T, Saito H. An Asian variant of intravascular large B-cell lymphoma: clinical pathological and cytogenetic approaches to diffuse large B-cell lymphoma associated with haemophagocytic syndrome. Br J Haematol. 2000;111(3):826–834. - PubMed
    1. Ponzoni M, Ferreri AJ, Campo E, Facchetti F, Mazzucchelli L, Yoshino T, Murase T, Pileri SA, Doglioni C, Zucca E, Cavalli F, Nakamura S. Definition diagnosis, and management of intravascular large B-cell lymphoma: proposals and perspectives from an international consensus meeting. J Clin Oncol. 2007;25(21):3168–3173. - PubMed

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