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Case Reports
. 2017 Apr;30(2):203-204.
doi: 10.1080/08998280.2017.11929587.

Plasmablastic plasmacytoma of the breast

Don K Le  1 , David Metter  1 , John R Krause  1
Affiliations
Case Reports

Plasmablastic plasmacytoma of the breast

Don K Le et al. Proc (Bayl Univ Med Cent). 2017 Apr.

Abstract

Breast plasmacytomas are extremely rare entities that can be seen as primary malignant neoplasms in the absence of bone involvement or as secondary neoplasms from disseminated multiple myeloma. Clinicians should be aware of this entity, as it may mimic benign and malignant lesions in the breast. Microscopically, immature plasmacytomas may mimic other neoplasms, so caution should be made on histological examination to ensure the correct diagnosis and corresponding therapy. Here we present a case of a plasmablastic plasmacytoma of the breast in a 55-year-old woman that was originally thought to be an angiosarcoma.

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Figures

Figure 1.
Figure 1.
(a) Solid mass of atypical plasma cells measuring 8.8 cm in greatest dimension. (b) Atypical cells with enlarged, eccentric nuclei and prominent nucleoli. There is background eosinophilic stroma. (c) CD138 immunostain is diffusely positive for plasma cells. (d) CD56 is positive in 50% of the plasma cells. (e) Kappa in situ hybridization is negative in plasma cells. (f) Lambda in situ hybridization is 100% positive in plasma cells.
See this image and copyright information in PMC

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