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. 2017 Apr;67(2):98-103.
doi: 10.1007/s13224-016-0937-4. Epub 2016 Aug 29.

Oral Misoprostol Solution for Induction of Labour

Varsha L Deshmukh  1 , Apurva V Rajamanya  1 , K A Yelikar  1
Affiliations

Oral Misoprostol Solution for Induction of Labour

Varsha L Deshmukh et al. J Obstet Gynaecol India. 2017 Apr.

Abstract

Objective: To determine the effects of oral misoprostol solution for induction of labour.

Study design: This is a prospective observational study.

Setting: This study was conducted in Government Medical College, Aurangabad.

Method: Patients undergoing induction of labour after 36 weeks of pregnancy were allocated by randomization to induction of labour with oral misoprostol solution administered 2 h apart. Delivery within 24 h after induction with oral misoprostol solution was the primary outcome on which the sample size was based. The data were analysed by Statistical Software for Social Sciences software.

Result: Two hundred patients were randomly selected for induction with oral misoprostol solution. There were no significant differences in substantive outcomes. Vaginal delivery within 24 h was achieved in 80.5 % of patients. The caesarean section rate was 19.5 %. Uterine hyperactivity occurred in 4 % of patients. The response to induction of labour in women with unfavourable cervices (modified Bishop's score <2) was somewhat slower with misoprostol, induction to delivery interval was more, oxytocin requirement was more, and vaginal delivery rate was less.

Conclusion: This new approach to oral misoprostol solution administration was successful in achieving vaginal delivery rate in 24 h in 80.5 % of patients; rate of LSCS was less 19.5 %.

Keywords: Induction of labour; Induction-delivery interval; Oral misoprostol solution.

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Conflict of interest statement

Conflict of interest

None.

Ethical Approval

Approval of ethical committee has been taken from Government Medical College, Aurangabad.

References

    1. Hofmeyr GJ, Alfirevic Z, Matonhodze B, et al. Titrated oral misoprostol solution for induction of labour: a multi-centre, randomised trial. RCOG2001, Br J Obstet Gynaecol. 2001;P11:S0306-5456(01)00231-5. - PubMed
    1. Mackenzie IZ. Induction of labour at the start of the new millennium. Reproduction. 2006;131(60):989–998. doi: 10.1530/rep.1.00709. - DOI - PubMed
    1. Saeed GA, Fakhar S, Nisar N, et al. Misoprostol for term labour induction: a randomized controlled trial. Taiwan J Obstet Gynecol. 2011;50(1):15–19. doi: 10.1016/j.tjog.2009.08.001. - DOI - PubMed
    1. Karali TT, Catalano T, Needham TE, et al. Mechanism of Misoprostol stabilization in hydroxyl-propylmethyl cellulose. Adv Exp Med Biol. 1991;302:275–289. doi: 10.1007/978-1-4899-0664-9_15. - DOI - PubMed
    1. Wing DA. Labour induction with misoprostol. Am J Obstet Gynaecol. 1999;181:339–345. doi: 10.1016/S0002-9378(99)70558-2. - DOI - PubMed

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