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. 2017 Jan-Mar;8(1):3-7.
doi: 10.4103/jpp.JPP_109_16.

Effect of Addition of Fentanyl and Clonidine to Local Anesthetic Solution in Peribulbar Block

Poonam Nehra  1 , Vrinda Oza  1 , Vandana Parmar  1 , Pooja Fumakiya  1
Affiliations

Effect of Addition of Fentanyl and Clonidine to Local Anesthetic Solution in Peribulbar Block

Poonam Nehra et al. J Pharmacol Pharmacother. 2017 Jan-Mar.

Abstract

Objective: To compare the effect of addition of fentanyl and clonidine as adjuvants to bupivacaine and lignocaine in peribulbar block.

Methods: The study was conducted on 105 adult patients of either sex, of ASA grade I and II undergoing ophthalmic surgeries. Patients were randomly divided into 3 groups of 35 each. All the patients were given peribulbuar block with 5ml lignocaine 2% +3 ml bupivacaine 0.5% +1 ml hyaluronidase (250 IU). In addition to this 1 ml normal saline was added to Group S, 25 μg fentanyl to Group F and 25 μg clonidine to Group C. Onset and duration of globe and lid akinesia, duration of sensory blockage and analgesia, hemodynamic parameters, number of rescue analgesic and visual analogue score were recorded.

Results: The mean time of onset of globe and lid akinesia was significantly faster in group F and group C compared to group S, mean duration of globe and lid akinesia was longer in Group F (207.71 + 13.54 and 143.14 + 7.86 min) and group C (213.52 + 14.52 and 162.06 + 17.1 min) compared to group S (117.78 + 10.42 and 87.64 + 9.76 min). The mean duration of analgesia was significantly longer in group F (217.71 + 12.67) and C (258.82 + 14.50 min) as compared to group S (131.39 + 9.63 min).

Conclusion: Addition of fentanyl or clonidine as adjuvant to local anaesthetic in peribulbar block provides faster onset and prolonged analgesia compared to local anaesthetic alone.

Keywords: Clonidine; fentanyl; peribulbar block; postoperative analgesia.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Pulse rate changes
Figure 2
Figure 2
Mean arterial pressure changes
Figure 3
Figure 3
First analgesic requirement
See this image and copyright information in PMC

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