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. 2017 Feb;5(1):32-36.
doi: 10.1177/2050640616642341. Epub 2016 Jun 22.

Family history is an independent risk factor for the progression of gastric atrophy among patients with Helicobacter pylori infection

Toshihiro Nishizawa  1 , Hidekazu Suzuki  2 , Kosuke Sakitani  3 , Hiroharu Yamashita  4 , Shuntaro Yoshida  5 , Keisuke Hata  6 , Takamitsu Kanazawa  7 , Naoto Fujiwara  8 , Takanori Kanai  9 , Naohisa Yahagi  10 , Osamu Toyoshima  11
Affiliations

Family history is an independent risk factor for the progression of gastric atrophy among patients with Helicobacter pylori infection

Toshihiro Nishizawa et al. United European Gastroenterol J. 2017 Feb.

Abstract

Background and aim: Risk factors for progression of gastric atrophy have not been fully elucidated. The aim of this study was to evaluate the risk factors for the development of atrophic gastritis in patients with Helicobacter pylori (H. pylori ) infection.

Methods: We reviewed 206 H. pylori-infected patients retrospectively. Endoscopic gastric atrophy was classified into closed- and open-type. We conducted univariate and multivariate logistic regression analyses on the contribution of age, sex, body mass index, past history of cancer, the first-degree family history of gastric cancer, habitual smoking and alcohol drinking, and endoscopic findings of gastric ulcer or duodenal ulcer for open-type gastric atrophy.

Results: On multivariate analysis, age (odds ratio = 1.079, 95% confidence interval = 1.048-1.11, p < 0.001), family history of gastric cancer (odds ratio = 3.967, 95% confidence interval = 1.414-10.6, p = 0.006) and duodenal ulcer (odds ratio = 0.834, 95% confidence interval = 0.711-0.977, p = 0.024) were the factors independently associated with open-type gastric atrophy.

Conclusions: A first-degree family history of gastric cancer, absence of duodenal ulcer, and old age were independent risk factors for the progression of gastric atrophy among H. pylori-infected patients. Careful examination with upper gastrointestinal endoscopy is necessary in patients with such risk factors.

Keywords: Atrophic gastritis; H. pylori; duodenal ulcer; family history; gastric cancer.

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References

    1. Nishizawa T, Suzuki H. Gastric Carcinogenesis and Underlying Molecular Mechanisms: Helicobacter pylori and Novel Targeted Therapy. Biomed Res Int 2015; 2015: 794378–794378. - PMC - PubMed
    1. Suzuki H, Nishizawa T, Tsugawa H, et al. Roles of oxidative stress in stomach disorders. J Clin Biochem Nutr 2012; 50: 35–39. - PMC - PubMed
    1. Naito Y, Takagi T, Okada H, et al. Expression of inducible nitric oxide synthase and nitric oxide-modified proteins in Helicobacter pylori-associated atrophic gastric mucosa. J Gastroenterol Hepatol 2008; 23(Suppl. 2): S250–S257. - PubMed
    1. Malfertheiner P, Megraud F, O’Morain CA, et al. Management of Helicobacter pylori infection – the Maastricht IV/Florence Consensus Report. Gut 2012; 61: 646–664. - PubMed
    1. Sugano K, Tack J, Kuipers EJ, et al. Kyoto global consensus report on Helicobacter pylori gastritis. Gut 2015; 64: 1353–1367. - PMC - PubMed