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Review
. 2016 Sep 14:2:21.
doi: 10.1186/s40813-016-0041-2. eCollection 2016.

Impact of two mycotoxins deoxynivalenol and fumonisin on pig intestinal health

Alix Pierron  1   2 , Imourana Alassane-Kpembi  1 , Isabelle P Oswald  1
Affiliations
Review

Impact of two mycotoxins deoxynivalenol and fumonisin on pig intestinal health

Alix Pierron et al. Porcine Health Manag. .

Abstract

Mycotoxins are secondary metabolites of fungi that grow on a variety of substrates. Due to their high consumption of cereals and their sensitivity, pigs are highly impacted by the presence of mycotoxins. At the European level, regulations and recommendations exist for several mycotoxins in pig feed. Among these toxins, fumonisin B1 (FB1), and deoxynivalenol (DON) have a great impact on the intestine and the immune system. Indeed, the intestine is the first barrier to food contaminants and can be exposed to high concentrations of mycotoxins upon ingestion of contaminated feed. FB1 and DON alter the intestinal barrier, impair the immune response, reduce feed intake and weight gain. Their presence in feed increases the translocation of bacteria; mycotoxins can also impair the immune response and enhance the susceptibility to infectious diseases. In conclusion, because of their effect on the intestine, FB1 and DON are a major threat to pig health, welfare and performance.

Keywords: Barrier function; Deoxynivalenol; Feed contamination; Fumonisin B1; Immune response; Intestine; Pig.

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Figures

Fig. 1
Fig. 1
Chemical structure of Fumonisin B1 and Deeoxynivalenol. These two mycotoxins belong to different families, with many different chemical structures and so various effects induced
Fig. 2
Fig. 2
Summary of the intestinal toxicity of the main mycotoxins present in feed pig. DON and FB1 can induce several effects on the intestine, with at the end a global impact on the pig intestinal health
See this image and copyright information in PMC

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