Rare Clinical Sign of Hodgkin's Lymphoma: Ocular Involvement

Abstract

Bilateral non-granulomatous anterior uveitis with left vitritis and macular edema were detected in a 19-year-old woman presenting with blurred vision in her left eye. Light microscopic study of the pathologic mediastinal lymph node that was detected via contrast computed tomography imaging during etiologic study revealed nodular sclerosing and mixed cellularity Hodgkin's lymphoma (HL). Ocular findings completely resolved with adriablastin, bleomycin, vinblastine, dacarbazine chemotherapy treatment. Herein, it is emphasized that HL should be remembered as one of the differential diagnoses in patients with ocular inflammatory pathologies such as uveitis and vasculitis. The ocular findings of HL are discussed.

Keywords: Anterior uveitis; Hodgkin’s lymphoma; Macular edema; posterior uveitis.

Figure 1. Color fundus photography from January 2012 showing normal OD (a) and indistinct optic disc margins and macular edema in OS (b). In early phase fluorescein angiography, OD appears normal (c) and leakage is evident in the disc and macula of the OS (d). In late phase, there is pronounced leakage around the disc and arcades in OD (e) and extensive leakage around the disc and arcades with macular edema in OS (f). Optical coherence tomography shows normal appearance in OD (g) and macular edema in OS (h) OD: Right eye, OS: Left eye

Figure 2. Appearance is normal in color fundus photograph (a, b) and optical coherence tomography images (c, d) from April 2012