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. 1988 Aug;85(15):5664-8.
doi: 10.1073/pnas.85.15.5664.

Immunological function of HLA-C antigens in HLA-Cw3 transgenic mice

O Dill  1 , F Kievits, S Koch, P Ivanyi, G J Hämmerling
Affiliations

Immunological function of HLA-C antigens in HLA-Cw3 transgenic mice

O Dill et al. Proc Natl Acad Sci U S A. 1988 Aug.

Abstract

The human major histocompatibility complex encodes three classical class I antigens, HLA-A, -B, and -C. Of these HLA-A and -B act as strong transplantation antigens and as restriction molecules for recognition of foreign antigen by cytotoxic T lymphocytes. In contrast, little is known about HLA-C and it is not clear whether HLA-C has the same functional properties as HLA-A and -B. Transgenic C57BL/6 mice expressing the HLA-Cw3 gene were established. Functional studies demonstrated that transgenic skin was rapidly rejected by normal C57BL/6 mice and that cytotoxic T lymphocytes generated by immunization of the Cw3 transgenic mice with influenza and Sendai virus were restricted by the Cw3 molecule. These data suggest that HLA-Cw3 has immunological functions comparable to those of HLA-A and -B.

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References

    1. Presse Med. 1969 May 10;77(23):849-52 - PubMed
    1. Immunogenetics. 1987;25(5):313-22 - PubMed
    1. Tissue Antigens. 1976 May;7(5):301-9 - PubMed
    1. Nature. 1977 Apr 7;266(5602):544-5 - PubMed
    1. Eur J Immunol. 1977 Aug;7(8):580-5 - PubMed

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