The impact of cellular senescence in skin ageing: A notion of mosaic and therapeutic strategies

Abstract

Cellular senescence is now recognized as one of the nine hallmarks of ageing. Recent data show the involvement of senescent cells in tissue ageing and some age-related diseases. Skin represents an ideal model for the study of ageing. Indeed, skin ageing varies between individuals depending on their chronological age but also on their exposure to various exogenous factors (mainly ultraviolet rays). If senescence traits can be detected with ageing in the skin, the senescent phenotype varies among the various skin cell types. Moreover, the origin of cellular senescence in the skin is still unknown, and multiple origins are possible. This reflects the mosaic of skin ageing. Senescent cells can interfere with their microenvironment, either via the direct secretion of factors (the senescence-associated secretory phenotype) or via other methods of communication, such as extracellular vesicles. Knowledge regarding the impact of cellular senescence on skin ageing could be integrated into dermatology research, especially to limit the appearance of senescent cells after photo(chemo)therapy or in age-related skin diseases. Therapeutic approaches include the clearance of senescent cells via the use of senolytics or via the cooperation with the immune system.

Keywords: 8-Methoxypsoralen (PubChem CID: 4114); Dasatinib (PubChem CID: 3062316); Genistein (PubChem CID: 5280961); MLN8237 (PubChem CID: 24771867); Navitoclax or ABT-263 (PubChem CID: 24978538); Nutlin-3 (PubChem CID: 216345); Piperlongumine (PubChem CID: 637858); Quercetin (PubChem CID: 5280343); Senescence; Senescence-associated secretory phenotype (SASP); Senolytic; Skin ageing; Stress-induced premature senescence (SIPS).