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Review
. 2017 Apr 14;120(8):1243-1245.
doi: 10.1161/CIRCRESAHA.116.310119.

Why Don't We Have Proven Treatments for HFpEF?

Jason Roh  1 , Nicholas Houstis  1 , Anthony Rosenzweig  2
Affiliations
Review

Why Don't We Have Proven Treatments for HFpEF?

Jason Roh et al. Circ Res. .

Abstract

The lack of effective treatments for heart failure with preserved ejection fraction (HFpEF) represents a large and growing unmet need in cardiology today. A critical obstacle to therapeutic innovation in HFpEF has been the absence of animal models that accurately recapitulate the complexities of the human disease. Here we propose that more comprehensive multi-organ system and functional phenotyping of preclinical models is essential if we are to maximize our chances of discovering and validating novel targets for effective therapeutic development in HFpEF.

Keywords: aging; cardiology; exercise; heart failure; models, animal.

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References

    1. https://www.nia.nih.gov.

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