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. 2017;57(4):969-974.
doi: 10.3233/JAD-170256.

A Critical Assessment of Research on Neurotransmitters in Alzheimer's Disease

P Hemachandra Reddy  1   2   3   4   5   6   7
Affiliations

A Critical Assessment of Research on Neurotransmitters in Alzheimer's Disease

P Hemachandra Reddy. J Alzheimers Dis. 2017.

Abstract

The purpose of this mini-forum, "Neurotransmitters and Alzheimer's Disease", is to critically assess the current status of neurotransmitters in Alzheimer's disease. Neurotransmitters are essential neurochemicals that maintain synaptic and cognitive functions in mammals, including humans, by sending signals across pre- to post-synaptic neurons. Authorities in the fields of synapses and neurotransmitters of Alzheimer's disease summarize the current status of basic biology of synapses and neurotransmitters, and also update the current status of clinical trials of neurotransmitters in Alzheimer's disease. This article discusses the prevalence, economic impact, and stages of Alzheimer's dementia in humans.

Keywords: Amyloid-β; cognitive decline; mitochondrial dysfunction; synaptic pathology.

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Figures

Fig. 1
Fig. 1
Neurotransmitters in a healthy synapse and an Alzheimer’s disease synapse.
See this image and copyright information in PMC

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