Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Apr 14;17(1):269.
doi: 10.1186/s12885-017-3239-z.

Serum low-density lipoprotein and low-density lipoprotein expression level at diagnosis are favorable prognostic factors in patients with small-cell lung cancer (SCLC)

Ting Zhou  1   2   3 , Jianhua Zhan  1   2   3 , Wenfeng Fang  1   2   3 , Yuanyuan Zhao  1   2   3 , Yunpeng Yang  1   2   3 , Xue Hou  1   2   3 , Zhonghan Zhang  1   2   3 , Xiaobo He  4 , Yaxiong Zhang  1   2   3 , Yan Huang  1   2   3 , Li Zhang  5   6   7
Affiliations

Serum low-density lipoprotein and low-density lipoprotein expression level at diagnosis are favorable prognostic factors in patients with small-cell lung cancer (SCLC)

Ting Zhou et al. BMC Cancer. .

Abstract

Background: Patients with small-cell lung cancer (SCLC) patients demonstrate varied survival outcomes. Previous studies have reported that lipoproteins are associated with prognosis in various cancers; however, the role of low-density lipoprotein (LDL) and low-density lipoprotein- cholesterol (LDLR) in patients with SCLC has not been studied.

Methods: In this study, the impact of LDL and LDLR on the prognosis of SCLC patients was evaluated. A total of 601 patients with SCLC were retrospectively evaluated, in which 198 patients had adequate tissues for immunohistochemistry, and serum LDL and LDLR expression levels at baseline were tested. X-tile tool, and univariate and multivariate Cox analysis were used to assess the association between LDL, LDLR and overall survival (OS).

Results: Univariate analysis demonstrated that a lower LDL level was significantly associated with superior OS (P = 0.037). Similarly, LDLR also significantly predicted OS (P = 0.003). Multivariate Cox analyses confirmed that lower LDL and LDLR expression was independent prognostic factors associated with longer OS (P = 0.019 and P = 0.027, respectively).

Conclusions: This study showed that both LDL and LDLR are prognostic indexes for survival in patients with SCLC. Patients with high LDL or LDLR expression level may benefit from treatment that modulates lipoprotein combined with platinum-based chemotherapy.

Keywords: Low-density lipoprotein; Low-density lipoprotein receptor; Prognosis; Small-cell lung cancer.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Representative images of immunostaining of LDLR expression based on different levels of expression (Original magnification 200×). a Low LDLR expression, b High LDLR expression. LDLR, low-density lipoprotein
Fig. 2
Fig. 2
Kaplein Meyer survival curves for patients with SCLC based on LDL levels. a Comparison of OS in overall patients based on LDL levels, b Comparison of OS in patients with limited stage based on LDL levels, c Comparison of PFS in patients based on LDL levels, d Comparison of OS in patients based on LDLR expression level. LDL: low-density lipoprotein; LDLR: low-density lipoprotein
Fig. 3
Fig. 3
Overall survival curves of patients with SCLC a Good vs bad PS, b Limited stage vs extensive stage, c Received TRT vs none, d Received PCI vs none. PS: performance status; TRT: thorax radiotherapy; PCI: prophylactic cranial irradiation
See this image and copyright information in PMC

References

    1. Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin. 2010;60(5):277–300. doi: 10.3322/caac.20073. - DOI - PubMed
    1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin. 2015;65(1):5–29. doi: 10.3322/caac.21254. - DOI - PubMed
    1. Govindan R, Page N, Morgensztern D, Read W, Tierney R, Vlahiotis A, et al. Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: analysis of the surveillance, epidemiologic, and end results database. J Clin Oncol. 2006;24(28):4539–4544. doi: 10.1200/JCO.2005.04.4859. - DOI - PubMed
    1. Herbst RS, Heymach JV, Lippman SM. Lung cancer. N Engl J Med. 2008;359(13):1367–1380. doi: 10.1056/NEJMra0802714. - DOI - PMC - PubMed
    1. Lally BE, Urbanic JJ, Blackstock AW, Miller AA, Perry MC. Small cell lung cancer: have we made any progress over the last 25 years? Oncologist. 2007;12(9):1096–1104. doi: 10.1634/theoncologist.12-9-1096. - DOI - PubMed

Publication types

LinkOut - more resources