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. 2017 May;35(2):171-174.
doi: 10.1016/j.ncl.2017.01.009.

Update on Alzheimer's and the Dementias: Introduction

John M Ringman  1
Affiliations

Update on Alzheimer's and the Dementias: Introduction

John M Ringman. Neurol Clin. 2017 May.

Abstract

Though the numbers of dementia cases are rising worldwide, there is evidence that incidence rates are decreasing. We now know that the neuropathological changes of Alzheimer's disease (AD) precede overt clinical signs by 15 to 20 years and we have biochemical and imaging markers that enable us to identify them. The genetic complexity of AD suggests it is not a single entity but rather represents a group of related diseases. The amyloid cascade hypothesis has led to the development of putative disease-modifying interventions but these have not yet been demonstrated to be substantively effective and additional approaches are warranted.

Keywords: Alzheimer’s disease; Amyloid cascade hypothesis; Dementia; Diagnostic criteria; Genetic; Intervention; Presymptomatic; Prevention.

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