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. 1988 Sep;62(9):3513-6.
doi: 10.1128/JVI.62.9.3513-3516.1988.

Duck hepatitis B virus (DHBV) particles produced by transient expression of DHBV DNA in a human hepatoma cell line are infectious in vitro

J C Pugh  1 , K Yaginuma, K Koike, J Summers
Affiliations

Duck hepatitis B virus (DHBV) particles produced by transient expression of DHBV DNA in a human hepatoma cell line are infectious in vitro

J C Pugh et al. J Virol. 1988 Sep.

Abstract

Transfection of the human hepatocellular carcinoma cell line HuH7 with a plasmid containing a tandem copy of the duck hepatitis B virus DNA sequence resulted in transient replication of the virus. Viral particles secreted by transfected HuH7 cells exhibited physical properties similar to those of serum-derived duck hepatitis B virus and were infectious in primary duck hepatocyte cultures.

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