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. 2017 May 16;8(20):32731-32740.
doi: 10.18632/oncotarget.16387.

Prognostic roles of Notch receptor mRNA expression in human ovarian cancer

Chuan Chen  1 , Xiaojiao Wang  2 , Shunping Huang  3 , Lin Wang  4 , Lili Han  4 , Songtao Yu  2
Affiliations

Prognostic roles of Notch receptor mRNA expression in human ovarian cancer

Chuan Chen et al. Oncotarget. .

Abstract

Aberrant activation of Notch signaling pathway has been correlated with high grade ovarian carcinoma and carcinogenesis. However, the predictive and prognostic values of Notch signaling pathway in ovarian cancer patients remains unclear. We utilize "The Kaplan-Meier plotter" (KM plotter) background database to access the prognostic values including overall survival (OS), progression-free survival (PFS), as well as post-progression survival (PPS) of four Notch receptor mRNA expression in ovarian cancer patients. Notch1 mRNA high expression was not correlated with OS, PFS and PPS for all ovarian cancer patients, but significantly correlated with poor PFS in TP53 wild type and favorite PFS in TP53 mutation type ovarian cancer patients. Notch2 mRNA high expression was significantly correlated with poor PFS for all ovarian cancer patients, especially in grade II patients. Notch3 mRNA high expression was significantly correlated with favorite PFS for all ovarian cancer patients. Notch4 mRNA high expression was significantly correlated with favorite OS, but not PFS and PPS for all ovarian cancer patients. The results strongly support that there are distinct prognostic values of four Notch receptor mRNA expression in ovarian cancer patients.

Keywords: KM plotter; Notch receptor; hazard ratio; mRNA expression; prognosis.

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Conflict of interest statement

CONFLICTS OF INTEREST

The authors have no financial involvement in this work.

Figures

Figure 1
Figure 1. For Notch1, its Affymetrix ID is 218902_at
(A) OS curves are plotted for ovarian cancer patients (n = 1,582). (B) PFS curves are plotted for ovarian cancer patients (n = 1,306). (C) PPS curves are plotted for ovarian cancer patients (n = 708).
Figure 2
Figure 2. For Notch2, its Affymetrix ID is 210756_s_at
(A) OS curves are plotted for all ovarian cancer patients (n = 1,582). (B) PFS curves are plotted for ovarian cancer patients (n = 1,306). (C) PPS curves are plotted for ovarian cancer patients (n = 708).
Figure 3
Figure 3. For Notch3, its Affymetrix ID is 203237_at
(A) OS curves are plotted for all ovarian cancer patients (n = 1,582). (B) PFS curves are plotted for ovarian cancer patients (n = 1,306). (C) PPS curves are plotted for ovarian cancer patients (n = 708).
Figure 4
Figure 4. For Notch4, its Affymetrix ID is 205247_at
(A) OS curves are plotted for all ovarian cancer patients (n = 1,582). (B) PFS curves are plotted for ovarian cancer patients (n = 1,306). (C) PPS curves are plotted for ovarian cancer patients (n = 708).
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