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. 2017 Apr 25;8(17):28502-28509.
doi: 10.18632/oncotarget.16093.

Human papillomavirus subtypes distribution among 2309 cervical cancer patients in West China

Kemin Li  1   2 , Rutie Yin  1   2 , Danqing Wang  1   2 , Qingli Li  1   2
Affiliations

Human papillomavirus subtypes distribution among 2309 cervical cancer patients in West China

Kemin Li et al. Oncotarget. .

Abstract

Objective: The prevalence of cervical Human Papillomavirus (HPV) infection in cervical cancer varies greatly worldwide, and HPV prevalence and genotypes in China are limited. The objective is to analyze the prevalence of HPV subtypes in cervical cancer patients in west China as well as the relationships between different histological types of cervical cancer and HPV subtypes.

Results: 2309 cases were included. 90.86% were infected with HPV, and the remaining 9.13% were negative. The most common subtypes were HPV16, HPV18, HPV58, HPV53, and HPV33. HPV16 and HPV18 appeared to be the most prevalent HPV subtypes across all age groups, while the prevalence of the other subtypes varied between age groups. A logistic regression analysis revealed that the occurrence of cervical squamous cell carcinoma and adenocarcinoma was most closely correlated to a persistent infection with HPV16 or HPV18, with P < 0.05.

Materials and methods: The prevalence of 27 HPV subtypes in 2309 cervical cancer patients who received treatment at our hospital between June 2011 and January 2016 was analyzed based on the results of HPV testing using Liquid suspension chip technology (Luminex 200).

Conclusions: HPV16 and HPV18 were the most prevalent HPV subtypes among the cervical cancer patients, followed by HPV58, HPV53, and HPV33. 9.13% of the cases appeared to not be associated with HPV. This suggests that HPV testing without the use of cytology may overlook some special types of cervical cancer that account for approximately 10% of all cervical cancer cases.

Keywords: West China; cervical cancer; distribution; human papillomavirus; prevalence.

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Conflict of interest statement

CONFLICTS OF INTEREST

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1. Overview of study population
Figure 2
Figure 2. Distribution of HPV in cervical cancer
Figure 3
Figure 3. Distribution of HPV in cervical cancer by age
Figure 4
Figure 4. Distribution of HPV in cervical squamous cell carcinoma, cervical adenocarcinoma, and cervical adenosquamous carcinoma
See this image and copyright information in PMC

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