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Review
. 2017 Apr 17;25(1):10.
doi: 10.1186/s40199-017-0175-z.

A guide to acquired vitamin K coagulophathy diagnosis and treatment: the Russian perspective

Valery V Wojciechowski  1 , Daniela Calina  2 , Konstantinos Tsarouhas  3 , Alexander V Pivnik  4 , Alexander A Sergievich  5 , Vladimir V Kodintsev  6 , Ekaterina A Filatova  7 , Eren Ozcagli  8 , Anca Oana Docea  9 , Andreea Letitia Arsene  10 , Eliza Gofita  9 , Christina Tsitsimpikou  11 , Aristidis M Tsatsakis  12   13   14 , Kirill S Golokhvast  15
Affiliations
Review

A guide to acquired vitamin K coagulophathy diagnosis and treatment: the Russian perspective

Valery V Wojciechowski et al. Daru. .

Abstract

Physicians often come across with cases of vitamin K antagonists-dependent coagulopathy for reasons such as accidental use of the vitamin K antagonists (VKA), excessive administration of prescribed anticoagulants of indirect action or not reported administration of vitamin K antagonists due to memory impairment and/or other mental disorders, even deliberate use thereof (attempt to murder or suicide). Rodenticide-poisoning (coumarins, warfarins) via food or occupational accidents are difficult to diagnose. This article discusses different types of acquired vitamin K-dependent coagulopathy. Differential diagnosis is primarily based on patient statements before additional causes of vitamin K deficiency are explored. Even when pathological vitamin K deficiency is not determined, appropriate and urgent medical treatment is necessary: administration of fresh frozen plasma or concentrated factors of the prothrombin complex, administration of vitamin K remedies along with symptomatic therapy. With early diagnosis and prescription of appropriate therapy, prognosis is favorable. Reasons for vitamin K antagonists-dependent coagulopathy cases.

Keywords: Acquired coagulopathy; Rodenticides; Vitamin K.

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Figures

Fig. 1
Fig. 1
Vitamin K deficiency
Fig. 2
Fig. 2
Warfarin and acenocoumarol mechanism of action
Fig. 3
Fig. 3
Chemical structures of anticoagulants of indirect action
Fig. 4
Fig. 4
Therapeutic approaches involving Vitamin K administration
See this image and copyright information in PMC

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