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. 2017 Jun 27;61(7):e00338-17.
doi: 10.1128/AAC.00338-17. Print 2017 Jul.

Dissemination of mcr-1-Carrying Plasmids among Colistin-Resistant Salmonella Strains from Humans and Food-Producing Animals in Taiwan

Chien-Shun Chiou  1 , Ying-Tsong Chen  2   3 , You-Wun Wang  4 , Yen-Yi Liu  4 , Hung-Chih Kuo  5 , Yeuh-Hua Tu  4 , Ann-Chi Lin  3 , Ying-Shu Liao  4 , Yu-Ping Hong  4
Affiliations

Dissemination of mcr-1-Carrying Plasmids among Colistin-Resistant Salmonella Strains from Humans and Food-Producing Animals in Taiwan

Chien-Shun Chiou et al. Antimicrob Agents Chemother. .

Abstract

We detected the colistin resistance gene mcr-1 in four Salmonella serovars isolated from humans and animals with diarrhea. The resistance gene was carried on different plasmids. One mcr-1-carrying conjugative plasmid, a variant of pHNSHP45, was disseminated among Salmonella isolates recovered from humans, pigs, and chickens.

Keywords: Salmonella enterica; antimicrobial drug resistance; colistin; plasmid; zoonosis.

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Figures

FIG 1
FIG 1
Genetic relationships among 19 mcr-1-carrying Salmonella isolates built using PFGE patterns, their corresponding antimicrobial resistance patterns, and relative information. Antimicrobials: FTX, cefotaxime; CAZ, ceftazidime; IMP, imipenem; NAL, nalidixic acid; CIP, ciprofloxacin; GEN, gentamicin; AMP, ampicillin; CHL, chloramphenicol; STR, streptomycin; SUL, sulfamethoxazole; TCY, tetracycline; SXT, trimethoprim-sulfamethoxazole; COL, colistin; EPT, ertapenem; FOX, cefoxitin. Red boxes, resistance; yellow boxes, intermediate resistance; green boxes, susceptibility. The plasmid types are defined on the basis of the BglII and AccI restriction profiles of the mcr-1-carrying conjugative plasmids from the isolates. ND, plasmid type not determined.
FIG 2
FIG 2
Genetic structures surrounding the mcr-1 gene in pP111, pR150626, pC214, and pNG14043 compared with that in pHNSHP45. Open reading frames and functions: red arrow, antimicrobial resistance and metal transporter; yellow arrow, transposition of mobile element; green arrow, virulence; blue arrow, plasmid replication; white arrow, unknown function.
See this image and copyright information in PMC

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