Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2017 Apr 18;8(16):26679-26686.
doi: 10.18632/oncotarget.15794.

Role of CD152 genetic polymorphisms in the susceptibility to breast cancer

Hai Chen  1 , Xiaodong Qi  1 , Xue Bai  1 , Ping Qiu  1 , Bin Chen  1
Affiliations
Meta-Analysis

Role of CD152 genetic polymorphisms in the susceptibility to breast cancer

Hai Chen et al. Oncotarget. .

Abstract

Background: The polymorphisms in cluster of differentiation 152 (CD152) gene have been reported to be associated with breast cancer (BC), but relevant findings were far from conclusive. Therefore, we carried out this meta-analysis to combine those results for a clearer perspective on this issue.

Results: In our meta-analysis, a total of 8 eligible publications of 19 case-control studies were selected, which totally contained 7,442 BC cases and 7,376 normal controls. Among the five polymorphisms of CD152 gene, +49 G/A, -1661 A/G and -318 C/T significantly increased the risk of BC under corresponding genetic comparisons; while CT60 G/A polymorphism was negatively related to the cancer susceptibility. In addition, -1772 T/C polymorphism of CD152 gene was not associated with the development of BC.

Materials and methods: Online databases and other sources were searched for published studies on the relationship between BC susceptibility and CD152 polymorphisms (+49 G/A, -1661 A/G, -1722 T/C, -318 C/T and CT60 G/A). The strength of association was evaluated with pooled odds ratios (ORs) and their corresponding 95% confidence intervals (95% CIs). Heterogeneity evaluation was conducted via Q test. Sensitivity analysis was used to detect the stability of our results. Begg's funnel plot and Egger's test were applied to investigate publication bias among selected studies.

Conclusions: The polymorphisms +49 G/A, -1661 A/G and -318 C/T may elevate the susceptibility to BC, but the polymorphism CT60 G/A may offer protection against the cancer.

Keywords: CD152; CTLA-4; breast cancer; immune response; polymorphisms.

PubMed Disclaimer

Conflict of interest statement

CONFLICTS OF INTEREST

None.

Figures

Figure 1
Figure 1. Flowchart of literature selection with detailed reasons for exclusion
Figure 2
Figure 2. Forest plot for the association between CD152 polymorphisms and breast cancer susceptibility under homozygote model
Figure 3
Figure 3. Forest plot for the association between CD152 polymorphisms and breast cancer susceptibility under heterozygote model
Figure 4
Figure 4. Begg's funnel plot for publication bias
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65:87–108. - PubMed
    1. DeSantis C, Ma J, Bryan L, Jemal A. Breast cancer statistics, 2013. CA Cancer J Clin. 2014;64:52–62. - PubMed
    1. Hery C, Ferlay J, Boniol M, Autier P. Changes in breast cancer incidence and mortality in middle-aged and elderly women in 28 countries with Caucasian majority populations. Annals of oncology. 2008;19:1009–1018. - PubMed
    1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69–90. - PubMed
    1. Ban KA, Godellas CV. Epidemiology of breast cancer. Surgical oncology clinics of North America. 2014;23:409–422. - PubMed

Publication types