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Meta-Analysis
. 2017 Jun 6;8(23):37263-37277.
doi: 10.18632/oncotarget.16146.

XPG gene polymorphisms and cancer susceptibility: evidence from 47 studies

Jiawen Huang  1 , Xiaoqi Liu  2 , Ling-Ling Tang  3 , Jian-Ting Long  4 , Jinhong Zhu  5 , Rui-Xi Hua  4 , Jufeng Li  1
Affiliations
Meta-Analysis

XPG gene polymorphisms and cancer susceptibility: evidence from 47 studies

Jiawen Huang et al. Oncotarget. .

Abstract

Xeroderma pigmentosum group G (XPG) is a single-strand-specific DNA endonuclease that functions in the nucleotide excision repair pathway. Genetic variations in XPG gene can alter the DNA repair capacity of this enzyme. We evaluated the associations between six single nucleotide polymorphisms (SNPs) in XPG (rs1047768 T>C, rs2296147 T>C, rs2227869 G>C, rs2094258 C>T, rs751402 C>T, and rs873601 G>A) and cancer risk. Forty-seven studies were identified in searches of the PubMed, Scopus, Web of Science, China National Knowledge Infrastructure, and WanFang databases. Crude odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a fixed or random effects model. We found that rs873601 G>A was associated with an increased overall cancer risk (AA vs. GG: OR = 1.14, 95% CI = 1.06-1.24; GA/AA vs. GG: OR = 1.08, 95% CI = 1.02-1.15; A vs. G: OR = 1.06, 95% CI = 1.02-1.10). In a stratified analysis, rs1047768 T>C was associated with an increased risk of lung cancer, rs2227869 G>C was associated with a decreased risk of cancer in population-based studies, and rs751402 C>T and rs873601 G>A were associated with the risk of gastric cancer. Our data indicate that rs873601 G>A is associated with cancer susceptibility.

Keywords: XPG; cancer; meta-analysis; polymorphism.

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Conflict of interest statement

CONFLICTS OF INTEREST

The authors declare that there are no conflicts of interest.

Figures

Figure 1
Figure 1. Flow diagram showing the process used to identify eligible studies
Figure 2
Figure 2. Forest plot of overall cancer risk associated with rs873601 G>A in the XPG gene under an allele contrast model
For each study, estimated ORs and 95% CIs are plotted with a box and horizontal line, respectively. (◇, pooled ORs and associated 95% CIs).
Figure 3
Figure 3. Funnel plot of the association between rs873601 G>A in the XPG gene and overall cancer risk under an allele contrast model
Each point represents an individual study that reported the indicated association.
Figure 4
Figure 4. TSA of rs873601 G>A in the XPG gene and overall cancer risk under an allele contrast model
See this image and copyright information in PMC

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References

    1. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136:E359–86. - PubMed
    1. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65:87–108. - PubMed
    1. Wood RD, Mitchell M, Sgouros J, Lindahl T. Human DNA repair genes. Science. 2001;291:1284–89. - PubMed
    1. Emmert S, Schneider TD, Khan SG, Kraemer KH. The human XPG gene: gene architecture, alternative splicing and single nucleotide polymorphisms. Nucleic Acids Res. 2001;29:1443–52. - PMC - PubMed
    1. O’Donovan A, Davies AA, Moggs JG, West SC, Wood RD. XPG endonuclease makes the 3’ incision in human DNA nucleotide excision repair. Nature. 1994;371:432–35. - PubMed

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