Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Apr;33(2):127-129.
doi: 10.1016/j.joa.2016.07.014. Epub 2016 Aug 30.

Comparison of hemodynamic effects of biventricular versus left ventricular only pacing in patients receiving cardiac resynchronization therapy: A before-after clinical trial

Babak Faghfourian Md  1   2 , Shahram Homayoonfar Md  1   2 , Mahdi Rezvanjoo Md  1 , Jalal Poorolajal Md PhD  3 , Amir Hossein Emam Md  2
Affiliations

Comparison of hemodynamic effects of biventricular versus left ventricular only pacing in patients receiving cardiac resynchronization therapy: A before-after clinical trial

Babak Faghfourian Md et al. J Arrhythm. 2017 Apr.

Abstract

Background: Biventricular (BiV) pacing is the most common mode of delivering cardiac resynchronization therapy (CRT). However, initial clinical studies have indicated that left ventricular (LV) pacing is not inferior to BiV pacing. This study was conducted to address whether LV only pacing can provide the same hemodynamic response as BiV pacing.

Methods: This before-after clinical trial was conducted at Ekbatan Hospital, from July 2012 to November 2014. Patients with a LV ejection fraction ≤35% and a QRS duration ≥0.12 s who had a standard indication for ventricular pacing were enrolled. The CRT devices of all patients had already been set for BiV pacing. Therefore, their CRT devices were set for LV only pacing for 3 months. The hemodynamic status of the patients was assessed by echocardiography before setting the CRT device to LV only pacing (as a control) and 3 months after (as an intervention).

Results: There was no statistically significant difference between the effect of BiV pacing and LV only pacing on the hemodynamic responses including LV ejection fraction, LV end diastolic and systolic volume, and velocity time integral of the aortic valve. Moreover, no significant difference was seen between men and women either.

Conclusions: LV only pacing is not inferior to BiV pacing, and the hemodynamic response was similar in the two groups. However, the LV mode has a number of advantages over the BiV mode. More evidence, based on large clinical trials, is needed to confirm our results.

Keywords: Biventricular pacing; Cardiac resynchronization therapy; Heart failure; Left ventricular only pacing.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. American Heart Association. Cardiac resynchronization therapy. AHA. Available from: 〈http://www.heart.org/HEARTORG/Conditions/HeartFailure/Cardiac-Resynchro...; 2014 [updated 02.01.13; cited 31.01.14].
    1. Abraham W.T. Rationale and design of a randomized clinical trial to assess the safety and efficacy of cardiac resynchronization therapy in patients with advanced heart failure: the Multicenter InSync Randomized Clinical Evaluation (MIRACLE) J Card Fail. 2000;6:369–380. - PubMed
    1. Iuliano S., Fisher S.G., Karasik P.E. QRS duration and mortality in patients with congestive heart failure. Am Heart J. 2002;143:1085–1091. - PubMed
    1. Fosbol E.L., Seibaek M., Brendorp B. Differential prognostic importance of QRS duration in heart failure and acute myocardial infarction associated with left ventricular dysfunction. Eur J Heart Fail. 2007;9:814–819. - PubMed
    1. Mansourati J., Heurteau M., Abalea J. Heart failure monitoring with a cardiac resynchronization therapy device-based cardiac contractility sensor: a case series. J Med Case Rep. 2014;8:27. - PMC - PubMed