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Case Reports
. 2017 Apr 6:21:82-83.
doi: 10.1016/j.rmcr.2017.04.004. eCollection 2017.

Adenocarcinoma of the lung presenting as thrombotic thrombocytopenic purpura

Ahmed Dirweesh  1 , Waqas Siddiqui  2 , Muhammad Khan  1 , Praneet Iyer  3 , Marc Seelagy  4
Affiliations
Case Reports

Adenocarcinoma of the lung presenting as thrombotic thrombocytopenic purpura

Ahmed Dirweesh et al. Respir Med Case Rep. .

Abstract

Acquired thrombotic thrombocytopenic purpura (TTP) usually presents as severe microangiopathic hemolytic anemia (MAHA) and thrombocytopenia in a previously healthy individual. It occurs in approximately three in one million adults and 1 in 10 million children annually. The incidence is increased in females and blacks. Diagnosing TTP and initiating therapy with plasma exchange is a must to avoid preventable complications. Acquired thromotic microangiopathy has been linked to collagen vascular diseases, use of certain medications, organ transplants, infections, pregnancy and cancer. We report a rare case of a 56-year-old African American male diagnosed with TTP who found to have an asymptomatic adenocarcinoma of the lung. Prompt cancer management resulted in completed remission of the thrombotic microangiopathy.

Keywords: Adenocarcinoma; Lung cancer; Thrombotic microangiopathy; Thrombotic thrombocytopenic purpura.

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Figures

Fig. 1
Fig. 1
A chest X-ray showing a 3 cm left upper lobe lung mass.
Fig. 2
Fig. 2
CT chest showing a 3 cm left upper lobe mass. No mediastinal lymphadenopathy was noted.
See this image and copyright information in PMC

References

    1. Gordon L.I., Kwaan H.C. Thrombotic microangiopathy manifesting as thrombotic thrombocytopenicpurpura/hemolytic uremic syndrome in the cancer patient. Semin. Thromb. Hemost. 1999;25(2):217–221. Review. PMID:10357089. - PubMed
    1. Von Hervay A., Illes A., Waldherr R. Pulmonary tumor thrombotic microangiopathy with pulmonary hypertension. Cancer. 1990;66:587–592. - PubMed
    1. Brill I.C., Robertson T.D. Subacute cor pulmonale. Arch. Intern Med. 1937;60:1043–1057.
    1. Witteles W.H., Schrier S.L., Wakelee H.A. Lung cancer presenting with amegakaryocytic thrombocytopenia. J. Clin. Oncol. 2008 Mar 1;26(7):1171–1174. - PubMed
    1. Reese J.A., Muthurajah D.S., Kremer Hovinga J.A., Vesely S.K., Terrell D.R., George J.N. Children and adults with thrombotic thrombocytopenic purpura associated with severe, acquired Adamts13 deficiency: comparison of incidence, demographic and clinical features. Pediatr. Blood Cancer. 2013 Oct;60(10):1676–1682. Epub 2013 Jun 1 PMID 23729372. - PubMed

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