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Review
. 2016 Jun 15;7(2):205-233.
doi: 10.1016/j.jtcme.2016.05.005. eCollection 2017 Apr.

Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives - A review

Augustine Amalraj  1 , Anitha Pius  2 , Sreerag Gopi  2 , Sreeraj Gopi  1
Affiliations
Review

Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives - A review

Augustine Amalraj et al. J Tradit Complement Med. .

Abstract

In recent years, several drugs have been developed deriving from traditional products and current drug research is actively investigating the possible therapeutic roles of many Ayruvedic and Traditional Indian medicinal therapies. Among those being investigated is Turmeric. Its most important active ingredient is curcuminoids. Curcuminoids are phenolic compounds commonly used as a spice, pigment and additive also utilized as a therapeutic agent used in several foods. Comprehensive research over the last century has revealed several important functions of curcuminoids. Various preclinical cell culture and animals studies suggest that curcuminoids have extensive biological activity as an antioxidant, neuroprotective, antitumor, anti-inflammatory, anti-acidogenic, radioprotective and arthritis. Different clinical trials also suggest a potential therapeutic role for curcuminoids in numerous chronic diseases such as colon cancer, lung cancer, breast cancer, inflammatory bowel diseases. The aim of this review is to summarize the chemistry, analog, metal complex, formulations of curcuminoids and their biological activities.

Keywords: Biological activity; Clinical study; Curcuma longa Linn; Curcumin; Curcuminoids.

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Figures

None
Graphical abstract
Fig. 1
Fig. 1
Chemical structures of important constituents present in turmeric.
Fig. 2
Fig. 2
Schematic representation of multiple biological activities of curcuminoids and their derivatives.
Fig. 3
Fig. 3
Various biological activities with different mechanism of curcuminoids and their derivatives.
See this image and copyright information in PMC

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