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Case Reports
. 2017 May;23(5):874-876.
doi: 10.3201/eid2305.161942.

mcr-1 Colistin Resistance in ESBL-Producing Klebsiella pneumoniae, France

Yvan Caspar, Mylène Maillet, Patricia Pavese, Gilles Francony, Jean-Paul Brion, Marie-Reine Mallaret, Richard Bonnet, Frédéric Robin, Racha Beyrouthy, Max Maurin
Case Reports

mcr-1 Colistin Resistance in ESBL-Producing Klebsiella pneumoniae, France

Yvan Caspar et al. Emerg Infect Dis. 2017 May.

Abstract

We report intestinal carriage of an extended-spectrum β-lactamase-producing Klebsiella pneumoniae strain with high-level resistance to colistin (MIC 24 mg/L) in a patient in France who had been hospitalized for fungal meningitis. The strain had the mcr-1 plasmid gene and an inactivated mgrB gene, which are associated with colistin resistance.

Keywords: ESBL; France; Klebsiella pneumoniae; antimicrobial resistance; bacteria; chronic granulomatous disease; colistin; extended-spectrum β-lactamase; fungal meningitis; infection control; mcr-1; mcr-1 coliitin resistance; meningitis/encephalitis; multidrug resistance; polymyxin.

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