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Case Reports
. 2017 May;23(5):827-829.
doi: 10.3201/eid2305.161936.

Amoxicillin and Ceftriaxone as Treatment Alternatives to Penicillin for Maternal Syphilis

Yuichi Katanami, Takehiro Hashimoto, Saho Takaya, Kei Yamamoto, Satoshi Kutsuna, Nozomi Takeshita, Kayoko Hayakawa, Shuzo Kanagawa, Norio Ohmagari
Case Reports

Amoxicillin and Ceftriaxone as Treatment Alternatives to Penicillin for Maternal Syphilis

Yuichi Katanami et al. Emerg Infect Dis. 2017 May.

Abstract

There is no proven alternative to penicillin for treatment of maternal syphilis. We report 2 case-patients with maternal syphilis who were successfully treated without penicillin. We used amoxicillin and probenecid for the first case-patient and amoxicillin, probenecid, and ceftriaxone for the second case-patient.

Keywords: Japan; Treponema pallidum; amoxicillin; bacteria; benzathine penicillin G; ceftriaxone; congenital syphilis; maternal syphilis; newborns; penicillin; pregnancy; probenecid; sexually transmitted infections; syphilis.

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References

    1. Wijesooriya NS, Rochat RW, Kamb ML, Turlapati P, Temmerman M, Broutet N, et al. Global burden of maternal and congenital syphilis in 2008 and 2012: a health systems modelling study. Lancet Glob Health. 2016;4:e525–33. 10.1016/S2214-109X(16)30135-8 - DOI - PMC - PubMed
    1. Bowen V, Su J, Torrone E, Kidd S, Weinstock H. Increase in incidence of congenital syphilis - United States, 2012-2014. MMWR Morb Mortal Wkly Rep. 2015;64:1241–5. 10.15585/mmwr.mm6444a3 - DOI - PubMed
    1. Workowski KA, Bolan GA; Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep. 2015;64(RR-03):1–137. - PMC - PubMed
    1. Kamidono S, Onodera S, Kishimoto T, Kiyota H, Teruya K, Kimura S, et al. Guidelines for diagnosis and treatment of sexually transmitted diseases, 2011 [in Japanese]. Japanese Journal of Sexually Transmitted Infections. 2011;22:2–163.
    1. National Institute of Infectious Diseases. Infectious Diseases Weekly Report (IDWR), Mar 2016. [in Japanese] [cited 2016 Nov 27]. http://www0.nih.go.jp/niid/idsc/idwr/IDWR2016/idwr2016-12.pdf

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