doi: 10.1016/0006-8993(88)90839-6.
Anticonvulsant effects of phencyclidine-like drugs: relation to N-methyl-D-aspartic acid antagonism
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- PMID: 2841999
- DOI: 10.1016/0006-8993(88)90839-6
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Anticonvulsant effects of phencyclidine-like drugs: relation to N-methyl-D-aspartic acid antagonism
Brain Res.
.
Abstract
Various compounds that have been identified in the literature as binding to the [3H]phencyclidine receptor site and as producing behavioral effects similar to phencyclidine (phencyclidine-like) protected mice from maximal electric shock-induced tonic-extensor seizures. These anticonvulsant effects appear to be due to blockade of the N-methyl-D-aspartic acid receptor, as recently reported for phencyclidine-like compounds. Phencyclidine-like compounds produced their anticonvulsant effects at doses that were also neurologically impairing.
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