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Randomized Controlled Trial
. 2017 Apr 14;9(4):389.
doi: 10.3390/nu9040389.

The Effect of Salt Intake and Potassium Supplementation on Serum Gastrin Levels in Chinese Adults: A Randomized Trial

Yuan-Yuan Wang  1 , Wen-Wen He  2 , Yan-Chun Liu  3 , Yi-Feng Lin  4 , Lu-Fei Hong  5
Affiliations
Randomized Controlled Trial

The Effect of Salt Intake and Potassium Supplementation on Serum Gastrin Levels in Chinese Adults: A Randomized Trial

Yuan-Yuan Wang et al. Nutrients. .

Abstract

Excess dietary salt is strongly correlated with cardiovascular disease, morbidity, and mortality. Conversely, potassium likely elicits favorable effects against cardiovascular disorders. Gastrin, which is produced by the G-cells of the stomach and duodenum, can increase renal sodium excretion and regulate blood pressure by acting on the cholecystokinin B receptor. The aim of our study was to assess the effects of altered salt and potassium supplementation on serum gastrin levels in humans. A total of 44 subjects (38-65 years old) were selected from a rural community in northern China. All subjects were sequentially maintained on a relatively low-salt diet for 7 days (3.0 g/day of NaCl), a high-salt diet for 7 days (18.0 g/day of NaCl), and then a high-salt diet supplemented with potassium for another 7 days (18.0 g/day of NaCl + 4.5 g/day of KCl). The high-salt intake significantly increased serum gastrin levels (15.3 ± 0.3 vs. 17.6 ± 0.3 pmol/L). This phenomenon was alleviated through potassium supplementation (17.6 ± 0.3 vs. 16.5 ± 0.4 pmol/L). Further analyses revealed that serum gastrin was positively correlated with 24 h urinary sodium excretion (r = 0.476, p < 0.001). By contrast, gastrin level was negatively correlated with blood pressure in all dietary interventions (r = -0.188, p = 0.031). The present study indicated that variations in dietary salt and potassium supplementation affected the serum gastrin concentrations in the Chinese subjects.

Keywords: blood pressure; gastrin; potassium; salt; sodium excretion.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The effect of relatively low-salt, high-salt intake and potassium supplementation on serum gastrin levels in all subjects (n = 44).
Figure 2
Figure 2
The correlation between serum gastrin levels and 24-h urinary sodium and potassium excretions in all subjects (n = 44) on a relatively low-salt diet, a high-salt diet, or on a high-salt diet with potassium supplementation.
Figure 3
Figure 3
The correlation between serum gastrin and MAP in all subjects (n = 44) on a relatively low-salt diet, high-salt diet, and high-salt diet with potassium supplementation.
See this image and copyright information in PMC

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