Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Apr 15;9(4):34.
doi: 10.3390/cancers9040034.

AR Signaling and the PI3K Pathway in Prostate Cancer

Megan Crumbaker  1   2 , Leila Khoja  3   4 , Anthony M Joshua  5   6   7
Affiliations
Review

AR Signaling and the PI3K Pathway in Prostate Cancer

Megan Crumbaker et al. Cancers (Basel). .

Abstract

Prostate cancer is a leading cause of cancer-related death in men worldwide. Aberrant signaling in the androgen pathway is critical in the development and progression of prostate cancer. Despite ongoing reliance on androgen receptor (AR) signaling in castrate resistant disease, in addition to the development of potent androgen targeting drugs, patients invariably develop treatment resistance. Interactions between the AR and PI3K pathways may be a mechanism of treatment resistance and inhibitors of this pathway have been developed with variable success. Herein we outline the role of the PI3K pathway in prostate cancer and, in particular, its association with androgen receptor signaling in the pathogenesis and evolution of prostate cancer, as well as a review of the clinical utility of PI3K targeting.

Keywords: AR signaling; PI3K; castrate resistant prostate cancer; prostate cancer.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest. Anthony Joshua holds a research grant from Astellas.

Figures

Figure 1
Figure 1
PI3K pathway targeting agents in development for the treatment of prostate cancer.
See this image and copyright information in PMC

References

    1. Globocan Prostate Cancer Incidence, Mortality and Prevalence Worldwide. [(accessed on 15 January 2017)]; Available online: http://globocan.iarc.fr/Pages/online.aspx.
    1. Beer T.M., Armstrong A.J., Rathkopf D.E., Loriot Y., Sternberg C.N., Higano C.S., Iversen P., Bhattacharya S., Carles J., Chowdhury S., et al. Enzalutamide in metastatic prostate cancer before chemotherapy. N. Engl. J. Med. 2014;371:424–433. doi: 10.1056/NEJMoa1405095. - DOI - PMC - PubMed
    1. De Bono J.S., Logothetis C.J., Molina A., Fizazi K., North S., Chu L., Chi K.N., Jones R.J., Goodman O.B., Jr., Saad F., et al. Abiraterone and increased survival in metastatic prostate cancer. N. Engl. J. Med. 2011;364:1995–2005. doi: 10.1056/NEJMoa1014618. - DOI - PMC - PubMed
    1. Ryan C.J., Smith M.R., Fizazi K., Saad F., Mulders P.F., Sternberg C.N., Miller K., Logothetis C.J., Shore N.D., Small E.J., et al. Abiraterone acetate plus prednisone versus placebo plus prednisone in chemotherapy-naive men with metastatic castration-resistant prostate cancer (COU-AA-302): Final overall survival analysis of a randomised, double-blind, placebo-controlled phase 3 study. Lancet Oncol. 2015;16:152–160. doi: 10.1016/S1470-2045(14)71205-7. - DOI - PubMed
    1. Scher H.I., Fizazi K., Saad F., Taplin M.E., Sternberg C.N., Miller K., de Wit R., Mulders P., Chi K.N., Shore N.D., et al. Increased survival with enzalutamide in prostate cancer after chemotherapy. N. Engl. J. Med. 2012;367:1187–1197. - PubMed