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Review
. 2017 Jul;18(7):425-432.
doi: 10.1111/tra.12488. Epub 2017 May 23.

The outer membrane vesicles: Secretion system type zero

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Free article
Review

The outer membrane vesicles: Secretion system type zero

Andrea Guerrero-Mandujano et al. Traffic. 2017 Jul.
Free article

Abstract

Gram-negative bacteria have mechanisms through which they can colonize and survive in different environments, such as the secretion systems types (1-6) that have been widely studied and characterized. Nowadays, some authors have proposed extracellular structures, such as the outer membrane vesicles (OMVs), to be considered as an additional and independent secretion system. The OMVs are spherical particles of 50-250 nm in diameter; they originate in the outer membrane, and therefore they have a very similar composition to the latter. These particles can transport an important variety of biomolecules: enzymes, toxins, antigenic determinants and even nucleic acids. Thus, it is of great interest to collect data describing the advantages of the transport of biomolecules through the OMVs and, thus, determine their role as a potential secretion system.

Keywords: bacteria; outer membrane vesicles; secretion system; virulence factor.

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