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. 2017 Dec;19(12):1183-1190.
doi: 10.1080/10286020.2017.1307192. Epub 2017 Apr 19.

Cytotoxic steroid derivatives from the Vietnamese soft coral Sinularia brassica

Hong Hanh Thi Tran  1 , Phong Nguyen Viet  1   2 , Thanh Nguyen Van  1 , Huong Thu Tran  2 , Cuong Nguyen Xuan  1   3 , Nam Nguyen Hoai  1 , Thung Do Cong  4 , Kiem Phan Van  1 , Minh Chau Van  1
Affiliations

Cytotoxic steroid derivatives from the Vietnamese soft coral Sinularia brassica

Hong Hanh Thi Tran et al. J Asian Nat Prod Res. 2017 Dec.

Abstract

Using various chromatographic separations, six ergostane-type steroids, including one new compound sinubrassione (1), and two pregnene-type steroid glycosides, including one new compound sinubrassioside (7), were isolated from methanol extract of the Vietnamese soft coral Sinularia brassica. The structure elucidation was confirmed by spectroscopic methods including 1D, 2D NMR and HR-ESI-MS. The cytotoxic activities of all the isolated compounds against three human cancer cell lines were also evaluated using MTT-based colorimetric assays.

Keywords: Sinularia brassica; cytotoxicity; soft coral; steroid; steroid glycoside.

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